Affinity Modulation of Epidermal Growth Factor Membrane Receptors by Biologically Active Phorbol and Ingenol Esters
Tumour promoters are compounds which are not themselves carcinogenic but which can induce tumours in mice previously treated with a suboptimal dose of certain chemical carcinogens. One of the most potent tumour promoting agents is TPA (12-O-tetradecanoyl-phorbol-13-acetate), initially isolated from croton oil. Tumour promoters modulate an array of biochemical functions in mouse skin, including the stimulation of DNA, RNA and protein synthesis. TPA also evokes various biological and biochemical changes when added to cultured cells, including the stimulation of DNA synthesis and cell proliferation, induction of plasminogen activator and ornithine decarboxylase, loss of surface-associated fibronectin, either inhibition or stimulation of differentiation, and alteration in cell permeability (1–6).
KeywordsNerve Growth Factor Active PHORBOL Multiplication Stimulate Activity Mink Cell Affinity Modulation
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- 1.B. L. Van Duuren, Prog. Exp. Tumour Res. 11: 31 (1969).Google Scholar
- 2.E. Hecker, Meth. Cancer Res. 6: 439 (1971).Google Scholar
- 4.T. J. Slaga, A. Sivak, and R. K. Boutwell, (eds) “Mechanisms of Tumor Promotion and Cocarcinogenesis”, Raven, New York (1978).Google Scholar
- 5.A. Sivak, Biochim. Biophys. Acta 560: 67 (1979).Google Scholar
- 8.M. Shoyab and G. J. Todaro, J. Biol. Chem. 255:8735 (198l).Google Scholar
- 12.V. H. Reynolds, F. H. Boehn, and S. Coren, Surg. Forum 16: 108 (1965).Google Scholar