Alterations in tRNA Metabolism as Markers of Neoplastic Transformation

  • Ronald W. Trewyn
  • Mark S. Elliott
  • Ronald Glaser
  • Michael R. Grever
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


Numerous changes in tRNA modification and catabolism are observed when cells undergo neoplastic transformation. The nature of certain of these changes is well established, while others require further characterization. Enzymes involved in the macromolecular modification of tRNA, the tRNA methyltransferases, exhibit idiosyncratic alterations during neoplastic transformation. These alterations include increases in enzyme specific activity as well as the appearance of different tRNA methyltransferases in the malignant tissue1,2. The increased tRNA methyltransferase activity and capacity observed in vitro for the enzymes isolated from transformed cells can also be correlated to increased methylation of specific tRNA iso accepting species, although not total tRNA, in vivo 3.


Acute Myelogenous Leukemia Neoplastic Transformation Chinese Hamster Cell Line Methylated Acute Myelogenous Leukemia Patient 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Ronald W. Trewyn
    • 1
    • 2
    • 3
  • Mark S. Elliott
    • 1
    • 2
    • 3
  • Ronald Glaser
    • 1
    • 2
    • 3
  • Michael R. Grever
    • 1
    • 2
    • 3
  1. 1.Department of Physiological Chemistry (R.W.T., M.S.E.)The Ohio State UniversityColumbusUSA
  2. 2.Department of Medical Microbiology & Immunology (R.G.)The Ohio State UniversityColumbusUSA
  3. 3.Department of Medicine (M.R.G.)The Ohio State UniversityColumbusUSA

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