Advertisement

Monoclonal Antibodies Specifying Antigens Associated with Rat Tumors and Their Use in Drug Delivery Systems

  • R. W. Baldwin
  • M. J. Embleton
  • M. V. Pimm
  • R. A. Robins
  • J. A. Jones
  • C. Holmes
  • Barbara Gunn
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)

Abstract

Neoplastic transformation results in the expression in transformed cells of antigens which are not present in their normal cell counterparts, at least in the adult host. One class of neoantigen expressed upon carcinogen-induced tumours and less frequently on naturally arising tumours was originally defined as a tumour specific transplantation antigen (Baldwin and Price 1981). The outstanding characteristic of these cell membrane associated products is their high degree of polymorphism so that tumours appear to express individually-distinct rejection antigens. Cell surface antigens with identical specificities have also been detected by interaction with antibody in sera from animals immunized against syngeneic tumour grafts, although the relationship of these antigens to the tumour rejection antigens has not been elucidated.

Keywords

Mammary Carcinoma Cell Surface Antigen Binding Ratio Fluorescence Activate Cell Sorter Analysis Foetal Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baldwin, R.W. and Embleton, M.J.,. 1979, Immunology of spontaneously arising rat mammary adenocarcinomas, Int. J. Cancer, 4: 430CrossRefGoogle Scholar
  2. Baldwin, R.W. and Embleton, M.J., 1970, Detection and isolation of tumour specific antigens associated with a spontaneously arising rat mammary carcinoma, Int. J. Cancer, 6: 373CrossRefGoogle Scholar
  3. Baldwin, R.W., Embleton, M.J., Price, M.R. and Vose, B.M., 1974, Embryonic antigen expression on experimental rat tumours, Transplant. Rev., 20: 77Google Scholar
  4. Baldwin, R.W., Embleton, M.J. and Price, M.R., 1981, Monoclonal antibodies specifying tumour-associated antigens and their potential for therapy, in: Molecular Aspects of Medicine 4/5:329, Pergamon Press, OxfordGoogle Scholar
  5. Baldwin, R.W. and Price, M.R., 1981, Neoantigen expression in chemical carcinogenesis, in: Cancer: A Comprehensive Treatise, Vol. 1, Plenum Press, New York, editor, F. Becker.Google Scholar
  6. Fishman, W.H. and Busch, H., 1979, Oncodevelopmental antigens, in: Methods in Cancer Research 18: 1, Academic Press, New YorkGoogle Scholar
  7. Gunn, B., Embleton, M.J., Middle, J. and Baldwin, R.W., 1980, Monoclonal antibody against a naturally occurring rat mammary carcinoma, Int. J. Cancer, 36: 325CrossRefGoogle Scholar
  8. Holmes, C.A., Austin, E.B., Embleton, M.J., Gunn, B. and Baldwin, R.W. Oncodevelopmental antigens associated with rat tumours specified by monoclonal antibodiesf in preparationGoogle Scholar
  9. Hurwitz, E., Levy, R., Maron, R., Wilchek, M.S., Arnon, R. and Sela, M., 1975, The covalent binding of daunomycin and adriamycin to antibodies with retention of both drug and antibody activities. Cancer Res. 35: 1175Google Scholar
  10. Jones, P.D.E., Robins, R.A. and Baldwin, R.W., Expression of Sp4/A4 monoclonal antibody defined antigen on mammary carcinoma Sp4 cells in preparationGoogle Scholar
  11. Murgita, R.A. and Wigzell, H., 1981, Regulation of immune functions in the fetus and newborn, Progress in Allergy, in pressGoogle Scholar
  12. Myers, C.E., 1980, Antitumor antibiotics I: anthracyclines in: Cancer Chemotherapy Annual 2, 66–83, ed. H.M. Pinedo, Excerpta MedicaGoogle Scholar
  13. Pimm, M.V., Tumour localisation of monoclonal antibody against a rat mammary carcinoma and suppression of tumour growth with adriamycin antibody conjugates, Cancer Immunol, and Immunother., in pressGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • R. W. Baldwin
    • 1
  • M. J. Embleton
    • 1
  • M. V. Pimm
    • 1
  • R. A. Robins
    • 1
  • J. A. Jones
    • 1
  • C. Holmes
    • 1
  • Barbara Gunn
    • 1
  1. 1.Cancer Research Campaign LaboratoriesUniversity of NottinghomNottinghamUK

Personalised recommendations