Monoclonal Antibodies Specifying Antigens Associated with Rat Tumors and Their Use in Drug Delivery Systems
Neoplastic transformation results in the expression in transformed cells of antigens which are not present in their normal cell counterparts, at least in the adult host. One class of neoantigen expressed upon carcinogen-induced tumours and less frequently on naturally arising tumours was originally defined as a tumour specific transplantation antigen (Baldwin and Price 1981). The outstanding characteristic of these cell membrane associated products is their high degree of polymorphism so that tumours appear to express individually-distinct rejection antigens. Cell surface antigens with identical specificities have also been detected by interaction with antibody in sera from animals immunized against syngeneic tumour grafts, although the relationship of these antigens to the tumour rejection antigens has not been elucidated.
KeywordsMammary Carcinoma Cell Surface Antigen Binding Ratio Fluorescence Activate Cell Sorter Analysis Foetal Antigen
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