Genetics of Human Cancer with Special Reference to Model Cancers

  • Alfred G. KnudsonJr.
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


If the somatic mutation hypothesis of cancer is correct then an understanding of the fundamental nature of cancer depends upon the isolation and characterization of the genes in which the critical mutations occur. So far we have two classes of genes that may help in this respect.


Homologous Chromosome Tumor Gene Gene Site Balance Translocation Retinoblastoma Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Alfred G. KnudsonJr.
    • 1
  1. 1.Fox Chase Cancer CenterPhiladelphiaUSA

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