The Immunogenetics of MHC Controlled Antigenic Determinants on Lewis-Lung-Carcinoma (3LL) Cells

  • N. Isakov
  • S. Katzav
  • P. De Baetselier
  • B. Tartakovsky
  • M. Feldman
  • S. Segal
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


The transplantation antigens controlled by the major histocompatibility complex (MHC) of mammals play a cardinal role in the control of immune processes. These alloantigens determine the ability to evoke effector cells directed against antigens expressed on malignant cells transformed by either chemical or viral carcinogens (1–4). MHC-encoded components may also control the qualitative outcome of an immune process directed against a given antigen on a certain malignant target cell. Thus, the preferential elicitation of antibody-producing cells, suppressor cells, killer cells, or lymphokines producing T cells against a cell-surface antigen may depend on the nature of the neighboring MHC components that form a complex with tumor antigens. Therefore, to elucidate immune tumor—host relations, one has to analyze both quantitatively and qualitatively whether MHC components expressed on tumor cells are different in their immunogenic properties from those expressed on normal somatic cells. Such differences might be relevant to the capacity of tumor cells to attack the immune barriers of the host and disseminate from its original site of growth to distant anatomical locations.


Spleen Cell Lewis Lung Carcinoma Normal Somatic Cell Syngeneic Host Allogeneic Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • N. Isakov
    • 1
  • S. Katzav
    • 1
  • P. De Baetselier
    • 1
  • B. Tartakovsky
    • 1
  • M. Feldman
    • 1
  • S. Segal
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

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