The Immunogenetics of MHC Controlled Antigenic Determinants on Lewis-Lung-Carcinoma (3LL) Cells
The transplantation antigens controlled by the major histocompatibility complex (MHC) of mammals play a cardinal role in the control of immune processes. These alloantigens determine the ability to evoke effector cells directed against antigens expressed on malignant cells transformed by either chemical or viral carcinogens (1–4). MHC-encoded components may also control the qualitative outcome of an immune process directed against a given antigen on a certain malignant target cell. Thus, the preferential elicitation of antibody-producing cells, suppressor cells, killer cells, or lymphokines producing T cells against a cell-surface antigen may depend on the nature of the neighboring MHC components that form a complex with tumor antigens. Therefore, to elucidate immune tumor—host relations, one has to analyze both quantitatively and qualitatively whether MHC components expressed on tumor cells are different in their immunogenic properties from those expressed on normal somatic cells. Such differences might be relevant to the capacity of tumor cells to attack the immune barriers of the host and disseminate from its original site of growth to distant anatomical locations.
KeywordsSpleen Cell Lewis Lung Carcinoma Normal Somatic Cell Syngeneic Host Allogeneic Recipient
Unable to display preview. Download preview PDF.
- 4.Wagner, H., Pfinzenmaier, K. and Rollinghoff, M. 1980. The role of the major histocompatibility gene complex in murine cytotoxic responses. Adv. Immunol. 31: 78.Google Scholar
- 5.Sugiura, K. and Stock, C.C. 1955. Studies in a tumor spectrum. III. The effects of phosphoramides on the growth of a variety of mouse and rat tumors. Cancer Res. 15: 38.Google Scholar
- 7.Isakov, N., Feldman, M. and Segal, S. 1981. Control of progression of local tumor and pulmonary metastases of the 3LL lung carcinoma by different histocompatibility requirements in mice. J. Natl. Cancer Inst., in press.Google Scholar
- 8.Isakov, N., Feldman, M. and Segal, S. 1981. An immune response against the alloantigens of the 3LL Lewis lung carcinoma prevents the growth of lung metastases, but not of local allografts. J. Inv. Metastases, in press.Google Scholar
- 11.Torrigiani, G. 1972. Quantitative estimation of antibody in the immunoglobulin classes of the mouse. II. Thymic dependence of the different classes. J. Immunol. 108: 161.Google Scholar
- 12.Bonavida, B. and Roman, J.M. 1979. Inappropriate alloantigen-like specificities detected on reticulum cell sarcoma of SJL/J mice. Immunogenetics 9: 318.Google Scholar
- 19.Martin, W.J. and Imamura, M. 1979. Variation in expression and immunogenicity of an H-2K coded alloantigen on murine tumors. Immunogenetics 9: 313.Google Scholar
- 29.Lonai, P., Katz, E. and Haran-Ghera, N. 1981. Role of the major histocompatibility complex in resistance to viral leukemia. Its effect on the preleukemic stage of leukemo- genesis. Cancer Biology Rev., in press.Google Scholar