Histocompatibility Antigens on the Cell Surface of Tumors

  • Giorgio Parmiani
  • Giuseppe Della Porta
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 57)


The histocompatibility antigens (HA) encoded by the MHC are a high polymorphic family of cell surface molecules whose function seems to have evolved to regulate the immune response of T lymphocytes to foreign antigens (Snell et al.,1976). The expression of the class I antigens of the MHC (i. e.: K, D or L gene products for the mouse and HLA-A, B and C for man) is widespread and virtually all the adult tissues studied display these antigens with the possible exception of placenta and B-cells of pancreas (Parr et al.,1979). A more selected tissue distribution is that of class II antigens, i. e. Ia for mice and DR for men.


Tumor Antigen Transitional Cell Carcinoma Histocompatibility Antigen Lymphocytic Choriomeningitis Reticulum Cell Sarcoma 
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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • Giorgio Parmiani
    • 1
  • Giuseppe Della Porta
    • 2
  1. 1.Divisions of Experimental Oncology BIstituto Nazionale TumoriMilanItaly
  2. 2.Divisions of Experimental Oncology AIstituto Nazionale TumoriMilanItaly

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