Abstract
Recombinant DNA technology (RDT) is a generic technology. It can be applied to the development of a wide range of product lines in diverse industrial settings. It enables one to design microbes with genetic capabilities to form products which otherwise could not be synthesized by means of fermentation.
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Hershfield, V., Boyer, H. W., Yanofsky, C., Lovett, M. A., and Helinski, D. R., 1974, Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA, Proc. Natl. Acad. Sci. USA 71:3455–3459.
Davis, M. G., and Calvo, J. M., 1977, Relationship between messenger ribonucleic acid and enzyme levels specified by the leucine Operon of Escherichia coli K-12, J. Bacteriol. 131:997–1007.
Panasenko, S. M., Cameron, J. R., Davis, R. W., and Lehman, I. R., 1977, Five hundredfold overproduction of DNA ligase after induction of a hybrid lambda lysogen constructed in vivo, Science 196:188–189.
Beppu, T., Nishimori, K., Kawaguchi, Y., Uchiyama, H., and Uozumi, T., 1980, Cloning of cDNA of calf prorennin in Escherichia coli, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 179.
Clot dissolving enzyme made by gene splicing, 1980, Chem. Eng. News, April 14, p. 6.
Goeddel, D. V., Kleid, D. G., Bolivar, F., Heyneker, H. L., Yansura, D. G., Crea, R., Hirose, T., Kraszewski, A., Itakura, K., and Riggs, A. D., 1979, Expression in Escherichia coli of chemically synthesized genes for human insulin, Proc. Natl. Acad. Sci. USA 76:106–110.
Goeddel, D. V., Heyneker, H. L., Hozumi, T., Arentzen, R., Itakura, K., Yansura, D. G., Ross, M. J., Miozzari, G., Crea, R., and Seeburg, P. H., 1979, Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone, Nature 281:544–548.
Martial, J. A., Hallewell, R. A., Baxter, J. D., and Goodman, H. M., 1979, Human growth hormones: Complementary DNA cloning and expression in bacteria, Science 205:602–607.
Burnett, J. P., 1980, Biosynthetic human insulin, Presentation at the Second Annual Biotechnology Investment Seminar, sponsored by E. F. Hutton, Inc., New York (September 17, 1980).
Burrell, C. J., MacKay, P., Greenaway, P. J., Hofschneider, P. H., and Murray, K., 1979, Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322, Nature 279:43–47.
Pasek, M., Goto, T., Gilbert, W., Zink, B., Schaller, H., MacKay, P., Leadbetter, G., and Murray, K., 1979, Hepatitis B virus genes and their expression in E. coli, Nature 282:575–579.
Charnay, P., Gervais, M., Louise, A., Galibert, F., and Tiollais, P., 1980, Biosynthesis of hepatitis B virus surface antigen in Escherichia coli, Nature 286:893–895.
Dubois, M-F., Pourcel, C., Rousset, S., Chany, C., and Tiollais, P., 1980, Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA, Proc. Natl Acad. Sci. USA 77:4549–4553.
Emtage, J. S., Tacon, W. C. A., Catlin, G. H., Jenkins, B., Porter, A. G., and Carey, N. H., 1980, Influenza antigenic determinants are expressed from haemagglutinin genes cloned in Escherichia coli, Nature 283:171–174.
Federal Register 45 (147):50528 (July 29, 1980).
Nagata, S., Taira, H., Hau, A., Johnsrud, L., Streuli, M., Ecsodi, J., Bou, W., Cantell, K., and Weissmann, C., 1980, Synthesis in E. coli of a polypeptide with human leukocyte interferon activity, Nature 284:316–320.
Masucci, M. G., Szigeti, R., Klein, E., Klein, G., Gruest, J., Montagnier, L., Taira, H., Hall, A., Nagata, S., and Weissmann, C., 1980, Effect of interferon-α1 from E. coli on some cell functions, Science 209:1431–1435.
Goeddel, D. V., Yelverton, E., Ullrich, A., Heyneker, H. L., Miozzari, G., Holmes, W., Seeburg, P. H., Dull, T., May, L., Stebbing, N., Crea, R., Maeda, S., Mc-Candliss, R., Sloma, A., Tabor, J. M., Gross, M., Familletti, P. C., and Pestka, S., 1980, Human leukocyte interferon produced by E. coli is biologically active, Nature 287:411–416.
Derynck, R., Remaut, E., Saman, E., Stanssens, P., DeClercq, E., Content, J., and Fiers, W., 1980, Expression of human fibroblast interferon gene in Escherichia coli, Nature 287:193–197.
Shine, J., Fettes, L, Lan, N. C. Y., Roberts, J. L., and Baxter, J. D., 1980, Expression of cloned β-endorphin gene sequences by Escherichia coli, Nature 285:456–461.
Genentech, Inc., Form S-l, Registration Statement under the Securities Act of 1933, Securities and Exchange Commission, Washington, D.C., August 19, 1980.
Fraser, T. H., and Bruce, B. J., 1978, Chicken ovalbumin is synthesized and secreted by Escherichia coli, Proc. Natl. Acad. Sci. USA 75:5936–5940.
Mercereau-Puijalon, O., Royal, A., Cami, B., Garapin, A., Krust, A., Gannon, F., and Kourilsky, P., 1978, Synthesis of an ovalbumin-like protein by Escherichia coli K12 harbouring a recombinant plasmid, Nature 275:505–510.
Mayer, H., Jaakkola, P., Schomer, U., Segner, A., Kemmer, T., and Wagner, F., 1980, Construction of an Escherichia coli strain with high penicillin G acylase-activity by gene cloning, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 179.
Bibb, M. J., Ward, J. M., and Hopwbod, D. A., 1978, Transformation of plasmid DNA into Streptomyces at high frequency, Nature 274:398–400.
Bibb, M., Schottel, J. M., and Cohen, S. N., 1980, A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces, Nature 284:526–531.
Mulligan, R. C, Howard, B. H., and Berg, P., 1979, Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome, Nature 277:108–114.
Mantei, N., Boll, W., and Weissmann, C., 1979, Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA, Nature 281:40–46.
Wold, B., Wigler, M., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R., 1979, Introduction and expression of a rabbit β-globin gene in mouse fibroblasts, Proc. Natl. Acad. Sci. USA 76:5684–5688.
Huttner, K. M., Scangos, G. A., and Ruddle, F. H., 1979, DNA-mediated gene transfer of a circular plasmid into murine cells, Proc. Natl. Acad. Sci. USA 76:5820–5824.
Cline, M. J., Stang, H., Mercola, K., Morse, L., Ruprecht, R., Browne, J., and Salser, W., 1980, Gene transfer in intact animals, Nature 284:422–425.
Mercola, K. E., Stang, H. D., Browne, J., Salser, W., and Cline, M. J., 1980, Insertion of a new gene of viral origin into bone marrow cells of mice, Science 208:1033–1035.
Sessions on fermented foods, 1980, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, pp. 140–149.
Doel, M. T., Eaton, M., Cook, E. A., Lewis, H., Patel, T., and Carey, N. H., 1980, The expression in E. coli of synthetic repeating polymeric genes coding for Poly[l-aspartyl-l-phenylalanine], Nucl. Acids Res. 8:4575–4592.
Gautier, F., 1980, Gene cloning for improvement of single cell production by methanol-utilizing bacteria, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 102.
Windass, J. D., Worsey, M. J., Pioli, E. M., Pioli, D., Barth, P. T., Atherton, K. T., Dart, E. C., Byrom, D., Powell, K., and Senior, P. J., 1980, Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus, Nature 287:396–401.
Chementator, 1979, Chem. Eng. (NY), October 22, p. 82.
Sessions on biological waste treatment and pollution control, 1980, VI International Fermentation Symposium, London, Ontario, Canada, pp. 108–118.
Session on hydrogen and methane production, 1980, VI International Fermentation Symposium, London, Ontario, Canada, pp. 72–76.
Murr, L. E., Torma, A. E., and Brierley, J. A. (eds.), 1978, Metallurgical Applications of Bacterial Leaching and Related Microbiological Phenomena, Academic Press, New York.
Chementator, 1980, Chem. Eng. (NY), September 8, p. 19.
Calvert, P., 1980, Industrial biopolymers, Nature 287:388.
Laskin, A. I., and Lechevalier, H. A. (eds.), 1974, Handbook of Microbiology, Volume 4, CRC Press, Cleveland.
Neidleman, S. L., Geigert, J., Amon, W. F., Liu, E., and Wolf, B., 1980, A unique multi-enzyme process for the production of alkene oxides, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 178.
High technology wave of the future or a market flash in the pan?, 1980, Business Week, November 10, pp. 86–98.
U.S. Bureau of the Census, Statistical Abstract of the United States: 1978, 99th edition, Washington, D.C.
Chem. Mark. Rep., March and April issues, 1980.
U.S. Department of Energy, personal communication, 1980.
United States International Trade Commission, 1979, Synthetic Organic Chemicals: United States Production and Sales, 1978 (USITC Publication 1001), U.S. Government Printing Office, Washington, D.C.
Hirose, Y., Sano, K., and Shibai, H., 1978, Amino acids, in: Annual Reports on Fermentation Processes, Volume 2 (D. Perlman, ed.), Academic Press, New York, pp. 155–189.
Hirose, Y., and Okada, H., 1979, Microbial production of amino acids, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 211–237.
Aunstrup, K., Andresen, O., Falch, E. A., and Nielsen, T. K., 1979, Production of microbial enzymes, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 281–309.
Danehy, J. P., and Wolnak, B. (eds.), 1980, Enzymes: The Interface Between Technology and Economics, Marcel Dekker, New York.
Smith, H., 1980, Presentation at the Second Annual Biotechnology Investment Seminar, sponsored by E. F. Hutton, Inc., New York (September 17, 1980).
Sebek, O. K., 1977, Biotransformation of steroid hormones and antibiotics, in:Biotechnological Applications of Proteins and Enzymes (Z. Bohak and N. Sharon, eds.), Academic Press, New York, p. 203.
Hirose, Y., Enei, H., and Shibai, H., 1979, Nucleosides and nucleotides, in: Annual Reports on Fermentation Processes, Volume 3 (D. Perlman, ed.), Academic Press, New York, pp. 253–274.
D. Perlman, 1979, Microbial production of antibiotics, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 241–276.
Ignoffo, C. M., and Anderson, R. F., 1979, Bioinsecticides, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 1–26.
National Institutes of Health, personal communication (1980).
National Science Foundation, personal communication (1980).
U.S. Department of Agriculture, personal communication (1980).
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Glick, J.L. (1983). Economic Impact of Recombinant DNA Technology. In: Fudenberg, H.H. (eds) Biomedical Institutions, Biomedical Funding, and Public Policy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4448-3_4
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DOI: https://doi.org/10.1007/978-1-4684-4448-3_4
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