Skip to main content
SpringerLink
Log in

Economic Impact of Recombinant DNA Technology

  • Chapter
Biomedical Institutions, Biomedical Funding, and Public Policy

Abstract

Recombinant DNA technology (RDT) is a generic technology. It can be applied to the development of a wide range of product lines in diverse industrial settings. It enables one to design microbes with genetic capabilities to form products which otherwise could not be synthesized by means of fermentation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hershfield, V., Boyer, H. W., Yanofsky, C., Lovett, M. A., and Helinski, D. R., 1974, Plasmid ColEl as a molecular vehicle for cloning and amplification of DNA, Proc. Natl. Acad. Sci. USA 71:3455–3459.

    Article  Google Scholar 

  2. Davis, M. G., and Calvo, J. M., 1977, Relationship between messenger ribonucleic acid and enzyme levels specified by the leucine Operon of Escherichia coli K-12, J. Bacteriol. 131:997–1007.

    Google Scholar 

  3. Panasenko, S. M., Cameron, J. R., Davis, R. W., and Lehman, I. R., 1977, Five hundredfold overproduction of DNA ligase after induction of a hybrid lambda lysogen constructed in vivo, Science 196:188–189.

    Google Scholar 

  4. Beppu, T., Nishimori, K., Kawaguchi, Y., Uchiyama, H., and Uozumi, T., 1980, Cloning of cDNA of calf prorennin in Escherichia coli, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 179.

    Google Scholar 

  5. Clot dissolving enzyme made by gene splicing, 1980, Chem. Eng. News, April 14, p. 6.

    Google Scholar 

  6. Goeddel, D. V., Kleid, D. G., Bolivar, F., Heyneker, H. L., Yansura, D. G., Crea, R., Hirose, T., Kraszewski, A., Itakura, K., and Riggs, A. D., 1979, Expression in Escherichia coli of chemically synthesized genes for human insulin, Proc. Natl. Acad. Sci. USA 76:106–110.

    Article  Google Scholar 

  7. Goeddel, D. V., Heyneker, H. L., Hozumi, T., Arentzen, R., Itakura, K., Yansura, D. G., Ross, M. J., Miozzari, G., Crea, R., and Seeburg, P. H., 1979, Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone, Nature 281:544–548.

    Article  Google Scholar 

  8. Martial, J. A., Hallewell, R. A., Baxter, J. D., and Goodman, H. M., 1979, Human growth hormones: Complementary DNA cloning and expression in bacteria, Science 205:602–607.

    Article  Google Scholar 

  9. Burnett, J. P., 1980, Biosynthetic human insulin, Presentation at the Second Annual Biotechnology Investment Seminar, sponsored by E. F. Hutton, Inc., New York (September 17, 1980).

    Google Scholar 

  10. Burrell, C. J., MacKay, P., Greenaway, P. J., Hofschneider, P. H., and Murray, K., 1979, Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322, Nature 279:43–47.

    Article  Google Scholar 

  11. Pasek, M., Goto, T., Gilbert, W., Zink, B., Schaller, H., MacKay, P., Leadbetter, G., and Murray, K., 1979, Hepatitis B virus genes and their expression in E. coli, Nature 282:575–579.

    Google Scholar 

  12. Charnay, P., Gervais, M., Louise, A., Galibert, F., and Tiollais, P., 1980, Biosynthesis of hepatitis B virus surface antigen in Escherichia coli, Nature 286:893–895.

    Google Scholar 

  13. Dubois, M-F., Pourcel, C., Rousset, S., Chany, C., and Tiollais, P., 1980, Excretion of hepatitis B surface antigen particles from mouse cells transformed with cloned viral DNA, Proc. Natl Acad. Sci. USA 77:4549–4553.

    Article  Google Scholar 

  14. Emtage, J. S., Tacon, W. C. A., Catlin, G. H., Jenkins, B., Porter, A. G., and Carey, N. H., 1980, Influenza antigenic determinants are expressed from haemagglutinin genes cloned in Escherichia coli, Nature 283:171–174.

    Google Scholar 

  15. Federal Register 45 (147):50528 (July 29, 1980).

    Google Scholar 

  16. Nagata, S., Taira, H., Hau, A., Johnsrud, L., Streuli, M., Ecsodi, J., Bou, W., Cantell, K., and Weissmann, C., 1980, Synthesis in E. coli of a polypeptide with human leukocyte interferon activity, Nature 284:316–320.

    Article  Google Scholar 

  17. Masucci, M. G., Szigeti, R., Klein, E., Klein, G., Gruest, J., Montagnier, L., Taira, H., Hall, A., Nagata, S., and Weissmann, C., 1980, Effect of interferon-α1 from E. coli on some cell functions, Science 209:1431–1435.

    Article  Google Scholar 

  18. Goeddel, D. V., Yelverton, E., Ullrich, A., Heyneker, H. L., Miozzari, G., Holmes, W., Seeburg, P. H., Dull, T., May, L., Stebbing, N., Crea, R., Maeda, S., Mc-Candliss, R., Sloma, A., Tabor, J. M., Gross, M., Familletti, P. C., and Pestka, S., 1980, Human leukocyte interferon produced by E. coli is biologically active, Nature 287:411–416.

    Article  Google Scholar 

  19. Derynck, R., Remaut, E., Saman, E., Stanssens, P., DeClercq, E., Content, J., and Fiers, W., 1980, Expression of human fibroblast interferon gene in Escherichia coli, Nature 287:193–197.

    Google Scholar 

  20. Shine, J., Fettes, L, Lan, N. C. Y., Roberts, J. L., and Baxter, J. D., 1980, Expression of cloned β-endorphin gene sequences by Escherichia coli, Nature 285:456–461.

    Article  Google Scholar 

  21. Genentech, Inc., Form S-l, Registration Statement under the Securities Act of 1933, Securities and Exchange Commission, Washington, D.C., August 19, 1980.

    Google Scholar 

  22. Fraser, T. H., and Bruce, B. J., 1978, Chicken ovalbumin is synthesized and secreted by Escherichia coli, Proc. Natl. Acad. Sci. USA 75:5936–5940.

    Article  Google Scholar 

  23. Mercereau-Puijalon, O., Royal, A., Cami, B., Garapin, A., Krust, A., Gannon, F., and Kourilsky, P., 1978, Synthesis of an ovalbumin-like protein by Escherichia coli K12 harbouring a recombinant plasmid, Nature 275:505–510.

    Article  Google Scholar 

  24. Mayer, H., Jaakkola, P., Schomer, U., Segner, A., Kemmer, T., and Wagner, F., 1980, Construction of an Escherichia coli strain with high penicillin G acylase-activity by gene cloning, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 179.

    Google Scholar 

  25. Bibb, M. J., Ward, J. M., and Hopwbod, D. A., 1978, Transformation of plasmid DNA into Streptomyces at high frequency, Nature 274:398–400.

    Article  Google Scholar 

  26. Bibb, M., Schottel, J. M., and Cohen, S. N., 1980, A DNA cloning system for interspecies gene transfer in antibiotic-producing Streptomyces, Nature 284:526–531.

    Article  Google Scholar 

  27. Mulligan, R. C, Howard, B. H., and Berg, P., 1979, Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome, Nature 277:108–114.

    Article  Google Scholar 

  28. Mantei, N., Boll, W., and Weissmann, C., 1979, Rabbit β-globin mRNA production in mouse L cells transformed with cloned rabbit β-globin chromosomal DNA, Nature 281:40–46.

    Article  Google Scholar 

  29. Wold, B., Wigler, M., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R., 1979, Introduction and expression of a rabbit β-globin gene in mouse fibroblasts, Proc. Natl. Acad. Sci. USA 76:5684–5688.

    Article  Google Scholar 

  30. Huttner, K. M., Scangos, G. A., and Ruddle, F. H., 1979, DNA-mediated gene transfer of a circular plasmid into murine cells, Proc. Natl. Acad. Sci. USA 76:5820–5824.

    Article  Google Scholar 

  31. Cline, M. J., Stang, H., Mercola, K., Morse, L., Ruprecht, R., Browne, J., and Salser, W., 1980, Gene transfer in intact animals, Nature 284:422–425.

    Article  Google Scholar 

  32. Mercola, K. E., Stang, H. D., Browne, J., Salser, W., and Cline, M. J., 1980, Insertion of a new gene of viral origin into bone marrow cells of mice, Science 208:1033–1035.

    Article  Google Scholar 

  33. Sessions on fermented foods, 1980, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, pp. 140–149.

    Google Scholar 

  34. Doel, M. T., Eaton, M., Cook, E. A., Lewis, H., Patel, T., and Carey, N. H., 1980, The expression in E. coli of synthetic repeating polymeric genes coding for Poly[l-aspartyl-l-phenylalanine], Nucl. Acids Res. 8:4575–4592.

    Article  Google Scholar 

  35. Gautier, F., 1980, Gene cloning for improvement of single cell production by methanol-utilizing bacteria, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 102.

    Google Scholar 

  36. Windass, J. D., Worsey, M. J., Pioli, E. M., Pioli, D., Barth, P. T., Atherton, K. T., Dart, E. C., Byrom, D., Powell, K., and Senior, P. J., 1980, Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus, Nature 287:396–401.

    Article  Google Scholar 

  37. Chementator, 1979, Chem. Eng. (NY), October 22, p. 82.

    Google Scholar 

  38. Sessions on biological waste treatment and pollution control, 1980, VI International Fermentation Symposium, London, Ontario, Canada, pp. 108–118.

    Google Scholar 

  39. Session on hydrogen and methane production, 1980, VI International Fermentation Symposium, London, Ontario, Canada, pp. 72–76.

    Google Scholar 

  40. Murr, L. E., Torma, A. E., and Brierley, J. A. (eds.), 1978, Metallurgical Applications of Bacterial Leaching and Related Microbiological Phenomena, Academic Press, New York.

    Google Scholar 

  41. Chementator, 1980, Chem. Eng. (NY), September 8, p. 19.

    Google Scholar 

  42. Calvert, P., 1980, Industrial biopolymers, Nature 287:388.

    Article  Google Scholar 

  43. Laskin, A. I., and Lechevalier, H. A. (eds.), 1974, Handbook of Microbiology, Volume 4, CRC Press, Cleveland.

    Google Scholar 

  44. Neidleman, S. L., Geigert, J., Amon, W. F., Liu, E., and Wolf, B., 1980, A unique multi-enzyme process for the production of alkene oxides, VI International Fermentation Symposium, London, Ontario, Canada, Abstract, p. 178.

    Google Scholar 

  45. High technology wave of the future or a market flash in the pan?, 1980, Business Week, November 10, pp. 86–98.

    Google Scholar 

  46. U.S. Bureau of the Census, Statistical Abstract of the United States: 1978, 99th edition, Washington, D.C.

    Google Scholar 

  47. Chem. Mark. Rep., March and April issues, 1980.

    Google Scholar 

  48. U.S. Department of Energy, personal communication, 1980.

    Google Scholar 

  49. United States International Trade Commission, 1979, Synthetic Organic Chemicals: United States Production and Sales, 1978 (USITC Publication 1001), U.S. Government Printing Office, Washington, D.C.

    Google Scholar 

  50. Hirose, Y., Sano, K., and Shibai, H., 1978, Amino acids, in: Annual Reports on Fermentation Processes, Volume 2 (D. Perlman, ed.), Academic Press, New York, pp. 155–189.

    Google Scholar 

  51. Hirose, Y., and Okada, H., 1979, Microbial production of amino acids, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 211–237.

    Google Scholar 

  52. Aunstrup, K., Andresen, O., Falch, E. A., and Nielsen, T. K., 1979, Production of microbial enzymes, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 281–309.

    Google Scholar 

  53. Danehy, J. P., and Wolnak, B. (eds.), 1980, Enzymes: The Interface Between Technology and Economics, Marcel Dekker, New York.

    Google Scholar 

  54. Smith, H., 1980, Presentation at the Second Annual Biotechnology Investment Seminar, sponsored by E. F. Hutton, Inc., New York (September 17, 1980).

    Google Scholar 

  55. Sebek, O. K., 1977, Biotransformation of steroid hormones and antibiotics, in:Biotechnological Applications of Proteins and Enzymes (Z. Bohak and N. Sharon, eds.), Academic Press, New York, p. 203.

    Google Scholar 

  56. Hirose, Y., Enei, H., and Shibai, H., 1979, Nucleosides and nucleotides, in: Annual Reports on Fermentation Processes, Volume 3 (D. Perlman, ed.), Academic Press, New York, pp. 253–274.

    Google Scholar 

  57. D. Perlman, 1979, Microbial production of antibiotics, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 241–276.

    Google Scholar 

  58. Ignoffo, C. M., and Anderson, R. F., 1979, Bioinsecticides, in: Microbial Technology, Volume 1, 2nd edition (H. J. Peppier and D. Perlman, eds.), Academic Press, New York, pp. 1–26.

    Google Scholar 

  59. National Institutes of Health, personal communication (1980).

    Google Scholar 

  60. National Science Foundation, personal communication (1980).

    Google Scholar 

  61. U.S. Department of Agriculture, personal communication (1980).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Genex Corporation, Rockville, Maryland, 20852, USA

    J. Leslie Glick

Authors
  1. J. Leslie Glick
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical University of South Carolina, Charleston, South Carolina, USA

    H. Hugh Fudenberg

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Glick, J.L. (1983). Economic Impact of Recombinant DNA Technology. In: Fudenberg, H.H. (eds) Biomedical Institutions, Biomedical Funding, and Public Policy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4448-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4448-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4450-6

  • Online ISBN: 978-1-4684-4448-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation