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Biology of Tolerance and Dependence

  • Boris Tabakoff
  • Jeffrey D. Rothstein

Abstract

Alcoholism is a heterogeneous phenomenon that involves maladaptive behavior, medical complications, and cultural attitudes, but all realistic definitions of alcoholism include reference to an individual’s tolerance to and dependence on ethanol (see Chapter 1). Alcohol tolerance and dependence, however, are not unidimen-sional entities; therefore it will be the purpose of this chapter to introduce the reader to the various facets of tolerance and dependence on ethanol, to discuss the implications of tolerance and dependence in promoting aberrant drinking behavior and alcohol-induced pathologies, and to describe the current treatment approaches used to manage the acute alcohol withdrawal syndrome.

Keywords

Withdrawal Syndrome Alcohol Withdrawal Physical Dependence Ethanol Tolerance Ethanol Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Boris Tabakoff
    • 1
    • 2
  • Jeffrey D. Rothstein
    • 3
  1. 1.Westside Veterans Administration Medical CenterChicagoUSA
  2. 2.Alcohol and Drug Abuse Research and Training Program, Department of Physiology and BiophysicsUniversity of Illinois at the Medical CenterChicagoUSA
  3. 3.Department of Physiology and BiophysicsUniversity of Illinois at the Medical CenterChicagoUSA

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