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Abstract

The familial nature of alcoholism has been known for centuries. However, only in recent times have scientists seriously begun to address the possibility that this disorder might be genetically influenced.

Keywords

Genetic Influence Twin Pair Alcohol Preference Alcohol Metabolism Drinking History 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams, K. M., Grant, I., Carlin, A. S., & Reed, R. Cross-study comparisons of self-reported alcohol consumption in four clinical groups. American Journal of Psychiatry, 1981, 134, 445–449.Google Scholar
  2. Blass, J. P., & Gibson, G. E. Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. New England Journal of Medicine, 1977, 297, 1367–1370.CrossRefGoogle Scholar
  3. Bohman, M. Some genetic aspects of alcoholism and criminality. Archives of General Psychiatry, 1978, 35, 269–276.CrossRefGoogle Scholar
  4. Bohman, M., Sigvardsson, S., & Cloninger, C. R. Maternal inheritance of alcohol abuse. Archives of General Psychiatry, 1981, 38, 965–969.CrossRefGoogle Scholar
  5. Bosron, W. F., & Li, T. K. Genetic determinants of alcohol and aldehyde dehydrogenases and alcohol metabolism. Seminars in Liver Disease, 1981, 1, 179–188.CrossRefGoogle Scholar
  6. Cadoret, R. J. Psychopathology in adopted-away offspring of biologic parents with antisocial behavior. Archives of General Psychiatry, 1978, 35, 176–184.CrossRefGoogle Scholar
  7. Cadoret, R. J., Cain, C. A., & Grove, W. M. Development of alcoholism in adoptees raised apart from alcoholic biologic relatives. Archives of General Psychiatry, 1980, 37, 561–563.CrossRefGoogle Scholar
  8. Cloninger, C. R., Christiansen, K. O., Reich, T., & Gottesman, I. I. Implications of sex differences in the prevalences of antisocial personality, alcoholism, and criminality for familial transmission. Archives of General Psychiatry, 1978, 35, 941–951.CrossRefGoogle Scholar
  9. Comings, D. E. Pcl Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis. Nature, 1979, 277, 28–32.CrossRefGoogle Scholar
  10. Cotton, N. S. The familial incidence of alcoholism: A review. Journal of Studies on Alcohol, 1979, 40, 89–116.Google Scholar
  11. Davis, V. E., & Walsh, M. J. Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction. Science, 1970, 167, 1005–1007.CrossRefGoogle Scholar
  12. Del Villano, B. C., Miller, S. I., Schacter, L. P., & Tischfield, J. A. Elevated superoxide dismutase in black alcoholics. Science, 1980, 207, 991–993.CrossRefGoogle Scholar
  13. Duby, J., & Schuckit, M. A. Subjective effects of alcohol intoxication in young men with alcoholic relatives. Presented at the National Council on Alcoholism Annual Scientific Meeting, New Orleans, La., 1981.Google Scholar
  14. Duncan, C., & Deitrich, R. A. A critical evaluation of tetrahydroisoquinoline induced ethanol preference in rats. Pharmacology, Biochemistry, and Behavior, 1980, 13, 1–17.CrossRefGoogle Scholar
  15. Dunner, D. L., Hensel, B. M., & Rieve, R. R. Bipolar illness: Factors in drinking behavior. American Journal of Psychiatry, 1979, 136, 583–585.Google Scholar
  16. Eriksson, K. Alcohol imbibition and behavior: A comparative genetic approach. Psychopharmaco-genetics. New York: Plenum Press, 1975.Google Scholar
  17. Frances, R. J., Timm, S., & Bucky, S. Studies of familial and nonfamilial alcoholism. Archives of General Psychiatry, 1980, 37, 564–566.CrossRefGoogle Scholar
  18. Freund, G., & O’Hollaren, P. Acetaldehyde concentrations in alveolar air following a standard dose of ethanol in man. Journal of Lipid Research, 1965, 6, 471–477.Google Scholar
  19. Gershon, E. S., Baron, M., & Leckman, J. F. Genetic models of the transmission of affective disorders. Journal of Psychiatric Research, 1975, 12, 301–317.CrossRefGoogle Scholar
  20. Goodwin, D. W., Schulsinger, F., Moller, N., Hermansen, L., Winokur, G., & Guze, S. B. Drinking problems in adopted and nonadopted sons of alcoholics. Archives of General Psychiatry, 1914, 31, 164–169.CrossRefGoogle Scholar
  21. Goodwin, D. W., Schulsinger, F., Knop, J., Mednick, S., & Guze, S. B. Psychopathology in adopted and nonadopted daughters of alcoholics. Archives of General Psychiatry, 1977, 34, 1005–1009.CrossRefGoogle Scholar
  22. Grieve, J., Griffiths, P. J., & Littleton, J. M. Genetic influences on the rate of development of ethanol tolerance and the ethanol physical withdrawal syndrome in mice. Drug and Alcohol Dependence, 1979, 4, 77–86.CrossRefGoogle Scholar
  23. Haglund, R. M. J., & Schuckit, M. A. The epidemiology of alcoholism. In N. Estes & E. Heinemann (Eds.), Alcoholism: Development, consequences and intervention. St. Louis: Mosby, 1977, 28–43.Google Scholar
  24. Hill, S. Y., Goodwin, D. W., Cadoret, R., Osterland, C. K., & Doner, S. M. Association and linkage between alcoholism and eleven serological markers. Journal of Studies on Alcohol, 1975, 36, 981–992.Google Scholar
  25. Hrubec, Z., & Omenn, G. S. Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances for alcoholism and its biologic end points by zygosity among male veterans. Alcoholism: Clinical and Experimental Research, 1981, 5, 207–214.CrossRefGoogle Scholar
  26. Jones, B. M., Jones, M. K., & Paredes, A. Oral contraceptives and ethanol metabolism. Alcohol Technical Reports, 1976, 5, 28–32.Google Scholar
  27. Jones, M. C. Personality correlates and antecedents of drinking patterns in adult males. Journal of Counseling and Clinical Psychology, 1968, 32, 2–12.CrossRefGoogle Scholar
  28. Kaij, L. Studies on the etiology and sequels of abuse of alcohol. Department of Psychiatry, University of Lund, Sweden, 1960.Google Scholar
  29. Korsten, M. A., Matsuzaki, S., Feinman, L., & Lieber, C. S. High blood acetaldehyde levels after ethanol administration. New England Journal of Medicine, 1975, 292, 386–389.CrossRefGoogle Scholar
  30. Lindros, K. O., Stowell, A., Pikkarainen, P., & Salaspuro, M. Elevated blood acetaldehyde in alcoholics with accelerated ethanol elimination. Pharmacology, Biochemistry, and Behavior, 1980, 13, 119–124.CrossRefGoogle Scholar
  31. Major, L. F., & Murphy, D. L. Platelet and plasma amine oxidase activity in alcoholic individuals. British Journal of Psychiatry, 1978, 132, 548–554.CrossRefGoogle Scholar
  32. Malila, A. Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake. Pharmacology, Biochemistry, and Behavior, 1978, 8, 197–201.CrossRefGoogle Scholar
  33. McClearn, G. E. Genetics and alcoholism simulacra. Alcoholism: Clinical and Experimental Research, 1979, 3, 255–258.CrossRefGoogle Scholar
  34. McCord, W., & McCord, J. Origins of alcoholism. Stanford, Calif.: Stanford University Press, 1960.Google Scholar
  35. Miller, W. R. Alcoholism scales and objective assessment methods: A review. Psychological Bulletin, 1976, 83, 649–674.CrossRefGoogle Scholar
  36. Myers, R. D. Tetrahydroisoquinolines in the brain: The basis of an animal model of alcoholism. Alcoholism: Clinical and Experimental Research, 1978, 2, 145–154.CrossRefGoogle Scholar
  37. Partanen, J., Bruun, K., & Markkanen, T., Inheritance of drinking behavior. Helsinki: Kekuskir-jopoino-Centraltryckeriet, 1966.Google Scholar
  38. Penick, E. C., Read, M. R., Crowley, P. A., & Powell, B. J. Differentiation of alcoholics by family history. Journal of Studies on Alcohol, 1978, 39, 1944–1948.Google Scholar
  39. Radlow, R., & Conway, T. L. Consistency of alcohol absorption in human subjects. Presented at The American Psychological Association Convention, Toronto, Canada, August 31, 1978.Google Scholar
  40. Randall, C. L., & Lester, D. Differential effects of ethanol and pentobarbital on sleep time in C57BL and BALB mice. Journal of Pharmacology and Experimental Therapeutics, 1974, 188, 27–33.Google Scholar
  41. Randall, C. L., & Lester, D. Social modification of alcohol consumption in inbred mice. Science, 1975, 189, 149–151.CrossRefGoogle Scholar
  42. Reed, T. E. Racial comparisons of alcohol metabolism: background, problems, and results. Alcoholism: Clinical and Experimental Research, 1978, 2, 83–87.CrossRefGoogle Scholar
  43. Reich, T., Winokur, G., & Mullaney, J. The transmission of alcoholism. In R. R. Fieve, D. Rosenthal, & W. Brill (Eds.), Genetic research in psychiatry. Baltimore: Johns Hopkins University Press, 1975.Google Scholar
  44. Robins, L. N. Sturdy childhood predictors of adult antisocial behaviour: replications from longitudinal studies. Psychological Medicine, 1978, 8, 611–622.CrossRefGoogle Scholar
  45. Saunders, G. R., & Schuckit, M. A. MMPI scores in young men with alcoholic relatives and controls. Journal of Nervous and Mental Disease, 1981, 169, 456–458.CrossRefGoogle Scholar
  46. Schaefer, J. M. Alcohol metabolism and sensitivity reactions among the Reddis of South India. Alcoholism: Clinical and Experimental Research, 1978, 2, 61–69.CrossRefGoogle Scholar
  47. Schneider, C. W., Trzil, P., & D’Andrea, R. Neural tolerance in high and low ethanol. Pharmacology, Biochemistry, and Behavior, 1974, 2, 549–551.CrossRefGoogle Scholar
  48. Schuckit, M. A. Alcoholism and sociopathy—diagnostic confusion. Quarterly Journal on the Studies of Alcohol, 1973, 34, 157–164.Google Scholar
  49. Schuckit, M. A. Alcoholism and genetics: possible biological mediators. Biological Psychiatry, 1980, 15, 437–447. (a)Google Scholar
  50. Schuckit, M. A. Self-rating of alcohol intoxication by young men with and without family histories of alcoholism. Journal of Studies on Alcohol, 1980, 41, 242–249. (b)Google Scholar
  51. Schuckit, M. A. A theory of alcohol and drug abuse: a genetic approach. In D. J. Lettieri, M. Sayers, & H. W. Pearson (Eds.), Theories on Drug Abuse. Washington, D.C.: NIDA Research Monograph 30, 1980, 297–302. (c)Google Scholar
  52. Schuckit, M. A. Biological markers: Metabolism and acute reactions to alcohol in sons of alcoholics. Pharmacology, Biochemistry, and Behavior, 1980, 13, 9–16. (d)CrossRefGoogle Scholar
  53. Schuckit, M. A. Peak blood alcohol levels in men at high risk for the future development of alcoholism. Alcoholism: Clinical and Experimental Research, 1981, 5, 64–66. (a)CrossRefGoogle Scholar
  54. Schuckit, M. A. Twin studies on substance abuse: An overview. In L. Gedda, P. Parisi, & W. Nance, Twin research 3. New York: Alan R. Liss, 1981. (b)Google Scholar
  55. Schuckit, M. A. Anxiety and assertiveness in relatives of alcoholics and controls. Journal of Clinical Psychiatry, 1982, 43, 238–239. (a)Google Scholar
  56. Schuckit, M. A. Gamma glutamyl-transferase values in nonalcoholic drinking men. American Journal of Psychiatry, 1982, 139, 227–228. (b)Google Scholar
  57. Schuckit, M. A., & Duby, J. Alcohol related flushing and the risk for alcoholism in sons of alcoholics. Journal of Clinical Psychiatry, 1982, 43, 415–418.Google Scholar
  58. Schuckit, M. A., & Haglund, R. M. J. An overview of the etiological theories on alcoholism. In N. J. Estes & M. E. Heinemann (Eds.), Alcoholism: Development, consequences, and interventions. St. Louis: Mosby, 1977.Google Scholar
  59. Schuckit, M. A., Goodwin, D. A., & Winokur, G. A study of alcoholism in half siblings. American Journal of Psychiatry, 1972, 128, 1132.Google Scholar
  60. Schuckit, M. A., O’Connor, D., Duby, J., Moss, M., & Vega, R. DBH activity levels in men at high risk for alcoholism and controls. Biological Psychiatry, 1981, 16, 1067–1075.Google Scholar
  61. Sheppard, J. R., Albersheim, P., & McClearn, G., Enzyme activities and ethanol preference in mice. Biochemistry and Genetics, 1968, 2, 205–212.CrossRefGoogle Scholar
  62. Sobell, M. B., Sobell, L. C., & Samuels, F. H. Validity of self-reports of alcohol-related arrests by alcoholics. Quarterly Journal of Studies on Alcohol, 1914, 35, 276–280.Google Scholar
  63. Spalt, L. Alcoholism: Evidence of an x-linked recessive genetic characteristic. Journal of the American Medical Association, 1979, 241, 2543.CrossRefGoogle Scholar
  64. Stabenau, J. R., & Hesselbrock, V. Assortative mating, family pedigree, and alcoholism. Substance and Alcohol Actions/Misuse, 1980, 1, 375–382.Google Scholar
  65. Sullivan, J. L., Stanfield, C. N., Schanberg, S., & Cavenar, J. Platelet monoamine oxidase and serum dopamine-B-hydroxylase activity in chronic alcoholics. Archives of General Psychiatry, 1978, 35, 1209–1212.CrossRefGoogle Scholar
  66. Sullivan, J. L., Cavenar, J. O., Maltbie, A. A., Lister, P., & Zung, W. K. Familial biochemical and clinical correlates of alcoholics with low platelet monoamine oxidase activity. Biological Psychiatry, 1979, 14, 385–394.Google Scholar
  67. Tabakoff, B., & Ritzmann, R. F. Acute tolerance in inbred and selected lines of mice. Drug and Alcohol Dependence, 1979, 4, 87–90.CrossRefGoogle Scholar
  68. Tabakoff, B., Ritzmann, R. F., Raju, T. S., & Deitrich, R. A. Characterization of acute and chronic tolerance in mice selected for inherent differences in sensitivity to ethanol. Alcoholism: Clinical and Experimental Research, 1980, 4, 70–73.CrossRefGoogle Scholar
  69. Truitt, E. B. Blood acetaldehyde levels after alcohol consumption by alcoholic and nonalcoholic subjects. Biological Aspects of Alcohol, 1971, 3, 212–232.Google Scholar
  70. Vesell, E. S. Ethanol metabolism: Regulation by genetic factors in normal volunteers under a controlled environment and the effect of chronic ethanol administration. Annals New York Academy of Sciences, 1975, 197, 79–88.CrossRefGoogle Scholar
  71. Whitehead, T. P., Clarke, C. A., & Whitfield, A. G. W. Biochemical and haematological markers of alcohol intake. Lancet, 1978, 1, 978–981.CrossRefGoogle Scholar

Books and Reviews

  1. Amit, Z., Brown, Z. W., Rockman, G. E., Smith, B., & Amir, S. Acetaldehyde: A positive reinforcer mediating alcohol consumption. In H. Begleiter (Ed.), Biological Effects of Alcohol. New York: Plenum Press, 1980, 413–423.Google Scholar
  2. Goodwin, D. W. Is alcoholism hereditary? New York: Oxford University Press, 1976, 51–84.Google Scholar
  3. Gottesman, I. I., & Shields, J. A critical review of recent adoption, twin, and family studies of schizophrenia: Behavioral genetics perspectives. Schizophrenia Bulletin, 1976, 2, 360–401.Google Scholar
  4. McClearn, G. E. The genetic aspects of alcoholism. In P. G. Bourne & R. Fox (Eds.), Alcoholism: Progress in research and treatment. New York: Academic Press, 1973, 337–358.Google Scholar
  5. Schuckit, M. A. A theory of alcohol and drug abuse: A genetic approach. In D. J. Lettieri, M. Sayers, & H. W. Pearson (Eds.), Theories on Drug Abuse. Washington, D.C.: NIDA Research Monograph 30, 1980, 297–302.Google Scholar
  6. Schuckit, M. A., & Haglund, R. M. J. An overview of the etiological theories on alcoholism. In N. J. Estes & M. E. Heinemann (Eds.), Alcoholism: Development, consequences, and interventions. St. Louis: C. V. Mosby, Co., 1977.Google Scholar
  7. Warner, R. H., & Rosett, H. L. The effects of drinking on offspring. An historical survey of the American and British literature. Journal of Studies on Alcohol, 1975, 36, 1395–1420.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Marc A. Schuckit
    • 1
    • 2
  1. 1.Alcohol Treatment ProgramVeterans Administration Medical CenterSan DiegoUSA
  2. 2.Department of PsychiatryUniversity of CaliforniaSan DiegoUSA

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