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Antecedents of Childhood Obesity

  • David P. Katz
  • Kim I. Timmers
  • Faith Winter
  • Jerome L. Knittle

Abstract

Obesity is one of the common medical problems currently confronting the physician. This problem has received increased attention, partly because of recognition that the prognosis of treating obesity in adults is extremely poor and that a high proportion of obese adults were obese children. Inasmuch as the results of long-term treatment of overtly obese children are no better than those observed in adults, prevention of the obese state is desirable to help patients who want to avoid a lifetime of dietary restriction.

Keywords

Adipose Tissue Obese Child Obese Subject Obese Adult Adipose Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lesser, G. T., and Zak, G., 1963, Measurement of total body fat in man by simultaneous absorption of two inert gases, Ann. N.Y. Acad. Sci. 110:40.PubMedGoogle Scholar
  2. 2.
    Brozek, J., Grande, F., Anderson, J. T., et al., 1963, Densitometrie analysis of body composition, Ann. N.Y. Acad. Sci. 110:113.PubMedGoogle Scholar
  3. 3.
    Owen, G. M., Jensen, R. L., and Fomon, S. J., 1962, Sex-related difference in total body water and exchangeable chloride during infancy, J. Pediatr. 60:858.PubMedGoogle Scholar
  4. 4.
    Forbes, G. B., 1964, Lean body mass and fat in obese children, Pediatrics 34:308.PubMedGoogle Scholar
  5. 5.
    Heald, F. P., Hunt, E. E., Schwartz, R., et al., 1963, Measures of body fat and hydration in adolescent boys, Pediatrics 31:226.PubMedGoogle Scholar
  6. 6.
    Wolff, O. H., 1955, Obesity in childhood, Q.J. Med. 24:109.PubMedGoogle Scholar
  7. 7.
    Quaade, F., 1964, Prevention of overnutrition, in: Symposia of the Swedish Nutrition Foundation (G. Blix, ed.), p. 25, Almqvist and Wiksells, Uppsala.Google Scholar
  8. 8.
    Jackson, R. L., and Kelly, H. G., 1945, Growth charts for use in pediatric practice, J. Pediatr. 27:215.Google Scholar
  9. 9.
    Stuart, H. C., and Meredith, H. V., 1946, Use of body measurements in the school health program, Am. J. Public Health 36:1365.Google Scholar
  10. 10.
    Johnson, M. L., Burke, B. S., and Mayer, J., 1956, The prevalence and incidence of obesity in cross section of elementary and secondary school children, Am. J. Clin. Nutr. 4:231.PubMedGoogle Scholar
  11. 11.
    Rose, H. E., and Mayer, J., 1968, Activity calorie intake and the energy balance of infants, Pediatrics 41:18.PubMedGoogle Scholar
  12. 12.
    Knittle, J. L., 1976, Obesity, in: Textbook of Paediatric Nutrition (D. S. McLaren, and D. Bruman, eds.), p. 192, Churchill Livingston, New York.Google Scholar
  13. 13.
    Harrison, G., White, M., and Goldsby, J. B., 1977, Relationship of birthweight to risk of infantile obesity, Pediatr. Res. 11:436.Google Scholar
  14. 14.
    Abraham, A., and Nordsieck, M., 1960, Relationship of excess weight in children and adults, Public Health Rep. 73:263.Google Scholar
  15. 15.
    Stunkard, A., D’Aquili, E., Fox, S., et al., 1972, Influence of social class on obesity and thinness in children, JAMA 221:579.PubMedGoogle Scholar
  16. 16.
    Whitelaw, A. G. L., 1976, Influence of maternal obesity on subcutaneous fat in the newborn, Br. Med. J. 1:985.PubMedGoogle Scholar
  17. 17.
    Frisancho, A. R., Klayman, J. E., and Matos, J., 1977, Influence of maternal nutritional status on prenatal growth in a Peruvanian urban population, Am. J. Phys. Anthropol. 46:265.PubMedGoogle Scholar
  18. 18.
    Gampel, B., 1965, The relationship of skinfold thickness in the neonates to sex, length of gestation, size at birth, and maternal skinfold, Hum. Biol. 37:29.PubMedGoogle Scholar
  19. 19.
    Udall, J. N., Harrison, G. G., Vaucher, Y., et al., 1978, Interaction of maternal and neonatal obesity, Pediatrics 62:17.PubMedGoogle Scholar
  20. 20.
    Forbes, G. B., 1977, Nutrition and growth, J. Pediatr. 91:40.PubMedGoogle Scholar
  21. 21.
    Whitelaw, A., 1977, Subcutaneous fat in newborn infants of diabetic mothers: An indication of quality of diabetic control, Lancet 1:15.PubMedGoogle Scholar
  22. 22.
    Oakley, N. W., Beard, R. W., and Turner, R. C., 1972, The effect of sustained maternal hyperglycaemia on the fetus in normal and diabetic pregnancies, Br. Med. J. 1:466.PubMedGoogle Scholar
  23. 23.
    Enzi, G., Inelman, E. M., Caretta, F., et al., 1980, Adipose tissue development “in utero.” Relationships between some nutritional and hormonal factors and body fat mass enlargement in newborns, Diabetologia 18:135.PubMedGoogle Scholar
  24. 24.
    Whaley, W. H., Zuspan, F. P., and Nelson, G. H., 1966, Correlation between maternal and fetal plasma levels of glucose and free fatty acids, Am. J. Obstet. Gynaecol 94:419.Google Scholar
  25. 25.
    Znamenacek, K., Pribylova, H., and Sabata, V., 1966, The effect of prenatal glucose and insulin infusion on carbohydrate metabolism in the newborn, Acta Paediatr. Scand. 55:452.PubMedGoogle Scholar
  26. 26.
    Coltart, T. M., Bearg, R. W., Turner, R. C., et al., 1969, Blood glucose and insulin relationships in the human mother and fetus before onset of labour, Br. Med. J. 4:17.PubMedGoogle Scholar
  27. 27.
    Beck, P., and Daughaday, W. H., 1967, Human placental lactogen: Studies of its acute metabolic effects and disposition in normal man, J. Clin. Invest. 46:103.PubMedGoogle Scholar
  28. 28.
    Samaan, N., Yen, S. S. C., Gonzales, D., et al., 1968, Metabolic effects of placental lactogen (HPL) in man, J. Clin. Endocrinol. Metab. 28:485.PubMedGoogle Scholar
  29. 29.
    Grumbach, M. M., Kaplan, J. L., Sciarra, J. J., et al., 1968, Chorionic growth hormone-prolactin (CGP): Secretion, disposition, biologic activity in man and postulated function of the “growth hormone” of the second half of pregnancy, Ann. N.Y.Acad. Sci. 148:501.PubMedGoogle Scholar
  30. 30.
    Williams, C., and Coltart, T. M., 1978, Adipose tissue metabolism in pregnancy: The lipolytic effect of human placental lactogen, Br. J. Obstet. Gynaecol. 85:43.PubMedGoogle Scholar
  31. 31.
    Tobin, J. D., Roux, J. F., and Soeldner, J. S., 1969, Human fetal insulin response after acute maternal glucose administration during labor, Pediatrics 44:668.PubMedGoogle Scholar
  32. 32.
    Obenshain, S. S., Adam, P. A. J., King, K. C., et al., 1972, Human fetal insulin response to sustained maternal hyperglycaemia, N. Engl. J. Med. 283:566.Google Scholar
  33. 33.
    Beard, R. W., Turner, R. C., and Oakley, N. W., 1971, Fetal response to glucose loading. Fetal blood glucose and insulin response to hyperglycaemia in normal diabetic pregnancies, Postgrad. Med. J. 47:68.Google Scholar
  34. 34.
    Mullins, A. G., 1958, The prognosis in juvenile obesity, Arch. Dis. Child. 33:307.PubMedGoogle Scholar
  35. 35.
    Weil, W. B., 1977, Current controversies in childhood obesity, J. Pediatr. 91:175.PubMedGoogle Scholar
  36. 36.
    Hirsch, J., 1975, Cell number and size as a determinant of subsequent obesity, in: Childhood Obesity (M. Winick, ed.), p. 15, John Wiley & Sons, New York.Google Scholar
  37. 36a.
    Lloyd, J. K., Wolff, O. H., and Whelen, W. S., 1961, Childhood obesity: A long-term study of height and weight, Br. Med. J. 2:45.Google Scholar
  38. 37.
    Robertson, A. F., and Lowry, G. H., 1964, Overweight children, Mich. Med. 63:629.PubMedGoogle Scholar
  39. 38.
    Asher, P., 1966, Fat babies and fat children: The prognosis of obesity in the very young, Arch. Dis. Child. 41:672.PubMedGoogle Scholar
  40. 39.
    Mossberg, H. O., 1948, Obesity in children: A clinical prognostical investigation. Acta Paeditr. 35: Suppl. 2.Google Scholar
  41. 40.
    Knittle, J. L., Timmers, K. I., Ginsberg-Fellner, F., et al., 1979, The growth of adipose tissue in children and adolescents: Cross-sectional and longitudinal studies of adipose cell number and size, J. Clin. Invest. 63:239.PubMedGoogle Scholar
  42. 41.
    Melbin, T., and Vuille, J. C., 1973, Physical development at 7 years of age in relation to velocity of weight gain in infancy with special reference to incidence of overweight, Br. J. Prev. Soc. Med. 27:225.Google Scholar
  43. 42.
    Eid, E. E., 1970, Follow-up study of physical growth of children who had excessive weight gain in first six months of life, Br. Med. J. 2:74.PubMedGoogle Scholar
  44. 43.
    Heald, F. P., and Hollander, R. J., 1965, The relationship between obesity in adolescence and early years, J. Pediatr. 67:35.PubMedGoogle Scholar
  45. 44.
    Charney, M., Goodman, H. C., McBride, M., et al., 1976, Childhood antecedents of adult obesity: Do chubby infants become obese adults? N. Engl. J. Med. 295:6.PubMedGoogle Scholar
  46. 45.
    Wilkinson, P. W., Parkin, J. M., Pearlson, J., et al., 1977, Obesity in childhood: A community study in Newcastle Upon Tyne, Lancet 1:350.PubMedGoogle Scholar
  47. 46.
    Bruch, H., 1939, Obesity in childhood. I. Physical growth and development of obese children, Am. J. Dis. Child. 58:457.Google Scholar
  48. 47.
    Fisch, R. O., Bilek, M. F., and Ulstrom, R., 1975, Obesity and leanness at birth and their relationship to body habitus in later childhood, Pediatrics 56:521.PubMedGoogle Scholar
  49. 48.
    Svenger, T., 1978, Does overnutrition or obesity during the first year affect weight at age four? Acta Paediatr. Scand. 67:465.Google Scholar
  50. 49.
    Poskitt, E. M. E., and Cole, T. J., 1977, Do fat babies stay fat? Br. Med. J. 1:7.PubMedGoogle Scholar
  51. 50.
    Taitz, L. S., 1977, Obesity in pediatric practice: Infantile obesity, Pediatr. Clin. North Aw. 24:107.Google Scholar
  52. 51.
    Ravelli, G. P., Stein, Z. A., and Susser, M. W., 1976, Obesity in young men after famine exposure in utero and early infancy, N. Engl. J. Med. 295:349.PubMedGoogle Scholar
  53. 52.
    Garn, S. M., and Clark, D. C., 1976, Trends in fatness and the origins of obesity, Pediatrics 57:443.PubMedGoogle Scholar
  54. 53.
    Hirsch, J., and Goldrick, R. B., 1964, Serial studies on the metabolism of human adipose tissue. I. Lipogenesis and free fatty acid uptake and release in small aspirated samples of subcutaneous fat, J. Clin. Invest. 43:1776.PubMedGoogle Scholar
  55. 54.
    Gurr, M. I., and Kirtland, J., 1978, Adipose tissue cellularity: A review. I. Techniques for studying cellularity, Int. J. Obesity 2:401.Google Scholar
  56. 55.
    Duckerts, M., and Bonnet, F., 1973, Adipose cell size differences related to the site of adipose tissue biopsy in children, Biomedicine 19:214.Google Scholar
  57. 56.
    Hirsch, J., and Knittle, J. L., 1970, Cellularity of obese and nonobese human adipose tissue, Fed. Proc. 29:1516.PubMedGoogle Scholar
  58. 57.
    Björntorp, P., and Sjöstrom, L., 1971, Number and size of adipose tissue fat cells in relation to metabolism in human obesity, Metabolism 20:703.PubMedGoogle Scholar
  59. 58.
    Salans, L. B., Cushman, S. W., and Weismann, R. E., 1973, Studies of human adipose tissue. Adipose cell size and number in nonobese and obese patients, J. Clin. Invest. 52:929.PubMedGoogle Scholar
  60. 59.
    Hirsch, J., and Batchelor, B., 1976, Adipose tissue cellularity in human obesity, Clin. Endocrinol. Metabol. 5:299.Google Scholar
  61. 60.
    Kirtland, J., and Gurr, M. I., 1979, Adipose tissue cellularity: A review. II. The relationship between cellularity and obesity, Int. J. Obesity 3:15.Google Scholar
  62. 61.
    Noppa, H., Bengtsson, C., Isaksson, B., et al., 1980, Adipose tissue cellularity in adulthood and its relation to childhood obesity, Int. J. Obesity 4:253.Google Scholar
  63. 62.
    Hager, A., Sjöstrom, L., Arvidsson, B., et al., 1977, Body fat and adipose tissue cellularity in infants: A longitudinal study, Metabolism 26:607.PubMedGoogle Scholar
  64. 63.
    Bonnet, F., Gosselin, L., Chantraine, J., et al., 1970, Adipose cell number and size in normal and obese children, Rev. Eur. Etud. Clin. Biol. 15:1101.PubMedGoogle Scholar
  65. 64.
    Naeye, R. L., and Roode, P., 1970, The sizes and numbers of cells in visceral organs in human obesity, Am. J. Clin. Pathol. 54:251.PubMedGoogle Scholar
  66. 65.
    Cheek, D. B., Schultz, R. B., Para, A., et al., 1970, Overgrowth of lean and adipose tissues in adolescent obesity, Pediatr. Res. 4:268.PubMedGoogle Scholar
  67. 66.
    Sjöstrom, L., and Björntorp, P., 1974, Body composition and adipose tissue cellularity in human obesity, Acta Med. Scand. 195:201.PubMedGoogle Scholar
  68. 67.
    Brook, C. G. D., Lloyd, J. K., and Wolf, O. H., 1972, Relation between age of onset of obesity and size and number of adipose cells, Br. Med. J. 2:25.PubMedGoogle Scholar
  69. 68.
    Brook, C. G. D., 1972, Evidence for a sensitive period in adipose cell replication in man, Lancet 2:624.PubMedGoogle Scholar
  70. 69.
    Hager, A., Sjöstrom, L., Arvidsson, B., et al., 1978, Adipose tissue cellularity in obese school girls before and after dietary treatment, Am. J. Clin. Nutr. 31:68.PubMedGoogle Scholar
  71. 70.
    Knittle, J. L., 1978, Adipose tissue development in man, in: Human Growth, Vol. 2, Postnatal Growth (F. Falkner and J. M. Tanner, eds.), p. 295, Plenum Press, New York.Google Scholar
  72. 71.
    Stern, J. S., and Greenwood, M. R. C., 1974, A review of development of adipose cellularity in man and animals, Fed. Proc. 33:1952.PubMedGoogle Scholar
  73. 72.
    Knittle, J. L., and Hirsch, J., 1968, Effect of early nutrition on the development of rat epididymal fat pads: Cellularity and metabolism, J. Clin. Invest. 47:2091.PubMedGoogle Scholar
  74. 73.
    Johnson, P. R., Stern, J. S., Greenwood, M. R. C., et al., 1973, Effect of early nutrition on adipose cellularity and pancreatic insulin release in the Zucker rat, J. Nutr. 103:738.PubMedGoogle Scholar
  75. 74.
    Boroumand, M., Miller, D. S., and Wise, A., 1980, The relative importance of genetics and diet in determining adipocyte number and size in the periovarian fat pad of the rat, Int. J. Obesity. 4:21.Google Scholar
  76. 75.
    Greenwood, M. R. C., and Hirsch, J., 1974, Postnatal development of adipocyte cellularity in the normal rat, J. Lipid Res. 15:474.PubMedGoogle Scholar
  77. 76.
    Johnson, P. R., Zucker, L. M., Cruce, J. A. F., et al., 1971, Cellularity of adipose depots in the genetically obese Zucker rat, J. Lipid Res. 12:706.PubMedGoogle Scholar
  78. 77.
    Lemonnier, D., 1972, Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high fat diet, J. Clin. Invest. 51:2907.PubMedGoogle Scholar
  79. 78.
    Faust, I. M., Johnson, P. R., and Hirsch, J., 1977, Surgical removal of adipose tissue alters feeding behavior and the development of obesity in rats, Science 197:393.PubMedGoogle Scholar
  80. 79.
    Klyde, B. J., and Hirsch, J., 1979, Increased cellular proliferation in adipose tissue of adult rats fed a high fat diet, J. Lipid Res. 20:705.PubMedGoogle Scholar
  81. 80.
    Faust, I. M., Johnson, P. R., and Hirsch, J., 1980, Long-term effects of early nutrition experience on the development of obesity in the rat, J. Nutr. 110:2027.PubMedGoogle Scholar
  82. 81.
    Björntorp, P., Carlgren, G., Isaksson, B., et al., 1975, Effect of an energy-reduced dietary regimen in relation to adipose cellularity in obese women, Am. J. Clin. Nutr. 28:445.PubMedGoogle Scholar
  83. 82.
    Ashwell, M., Durrant, M., and Garrow, J. S., 1978, Does adipose cellularity or the age of onset of obesity influence the response to short-term inpatient treatment of obese women? Int. J. Obesity 2:449.Google Scholar
  84. 83.
    Krotkiewski, M., Sjöstrom, L., Björntorp, P., et al., 1977, Adipose cellularity in relation to prognosis for weight reduction, Int. J. Obesity 1:395.Google Scholar
  85. 84.
    Johnson, M. L., Burke, B. S., and Mayer, J., 1956, Relative importance of inactivity and overeating in the energy balance of obese high school girls, Am. J. Clin. Nutr. 4:37.PubMedGoogle Scholar
  86. 85.
    Griffiths, M., and Payne, P. R., 1976, Energy expenditure in small children of obese and nonobese parents, Nature 260:698.PubMedGoogle Scholar
  87. 86.
    Stern, J. S., and Johnson, P. R., 1977, Spontaneous activity and adipose cellularity in the genetically obese Zucker rat (fa/fa), Metabolism 26:371.PubMedGoogle Scholar
  88. 87.
    Godbole, V., York, D. A., and Bloxham, D. P., 1978, Developmental changes in the fatty (fa/fa) rat: Evidence for defective thermogenesis preceding the hyperlipogenesis and hyperinsulinemia, Diabetologia 15:41.PubMedGoogle Scholar
  89. 88.
    Young, R. A., Tulp, O. L., and Horton, E. S., 1980, Thyroid and growth responses of young Zucker obese and lean rats to a low-protein-high-carbohydrate diet, J. Nutr. 110:1421.PubMedGoogle Scholar
  90. 89.
    Thenen, S. W., and Carr, R. H., 1980, Influence of thyroid hormone treatment on growth, body composition, and metabolism during cold stress in genetically obese mice, J. Nutr. 110:189.PubMedGoogle Scholar
  91. 90.
    Lin, P., Romsos, D. R., Vander Tuig, J. G., et al., 1979, Maintenance energy requirements, energy retention, and heat production of young obese (ob/ob) and lean mice fed a high-fat or a high-carbohydrate diet, J. Nutr. 109:1143.PubMedGoogle Scholar
  92. 91.
    Trayhurn, P., and Fuller, L., 1980, The development of obesity in genetically diabetic-obese (db/db) mice pair-fed with lean siblings: The importance of thermoregulatory thermogenesis, Diabetologia 19:148.PubMedGoogle Scholar
  93. 92.
    Chee, K. M., Romsos, D. R., and Bergen, W. G., 1981, Effect of dietary fat on protein regulation in young obese and lean mice, J. Nutr. 111:668.PubMedGoogle Scholar
  94. 93.
    Dunn, M. A., and Hortsook, E. W., 1980, Comparative amino acid and protein metabolism in obese and nonobese Zucker rats, J. Nutr. 110:1865.PubMedGoogle Scholar
  95. 94.
    Martin, R. J., and Gahagan, J., 1977, Serum hormone levels and tissue metabolism in pair-fed lean and obese Zucker rats, Horm. Metab. Res. 9:181.PubMedGoogle Scholar
  96. 95.
    Sims, E. A. H., Horton, E. S., and Salans, L. B., 1971, Inducible metabolic abnormalities during development of obesity, Annu. Rev. Med. 22:235.PubMedGoogle Scholar
  97. 96.
    Harris, P. M., and Widdowson, E. M., 1978, Deposition of fat in the body of the rat during rehabilitation after early undernutrition, Br. J. Nutr. 39:201.PubMedGoogle Scholar
  98. 97.
    Ozelci, A., Romsos, D. R., and Leveille, G. A., 1978, Influence of initial food restriction on subsequent body weight gain and body fat accumulation in rats, J. Nutr. 108:1724.PubMedGoogle Scholar
  99. 98.
    Timmers, K. I., and Knittle, J. L., 1980, Effects of undernutrition and refeeding on enzyme activities and rates of glucose catabolism in rat epididymal adipose tissue, J. Nutr. 110:1176.PubMedGoogle Scholar
  100. 99.
    Paik, H. S., and Yearick, E. S., 1978, The influence of dietary fat and meal frequency on lipoprotein lipase and hormone-sensitive lipase in rat adipose tissue, J. Nutr. 108:1798.PubMedGoogle Scholar
  101. 100.
    Dorner, G., 1974, Environment-dependent brain differentiation and fundamental processes of life, Acta Biol. Med. Ger. 33:129.PubMedGoogle Scholar
  102. 101.
    Ginsberg-Fellner, F., and Knittle, J. L., 1973, Adipose tissue cellularity and metabolism in newly diagnosed juvenile diabetics, Diabetes 22:528.PubMedGoogle Scholar
  103. 102.
    Maruhama, Y., and Abe, R., 1981, A familial form of obesity without hyperinsulinism at the outset, Diabetes 30:14.PubMedGoogle Scholar
  104. 103.
    Edwards, L. E., Dickes, W. F., Alton, T. R., et al., 1978, Pregnancy in the massively obese: Course, outcome, and obesity prognosis of the infant, Am. J. Obstet. Gynecol. 131:479.PubMedGoogle Scholar
  105. 104.
    Food and Nutrition Board, 1980, Recommended Dietary Allowances, Ninth Edition, National Research Council—National Academy of Sciences, Washington.Google Scholar
  106. 105.
    Neumann, C. G., and Apough, M., 1976, Birthweight doubling time: A fresh look, Pediatrics 57:469.PubMedGoogle Scholar
  107. 106.
    Lawrence, R., 1980, Breast Feeding. A Guide for the Medical Profession. C. V. Mosby Co., St. Louis, Toronto, London.Google Scholar
  108. 107.
    Taitz, L. S., 1976, Infantile overnutrition among artificially fed infants, Br. Med. J. 1:315.Google Scholar
  109. 108.
    Hall, B., 1975, Changing composition of human milk and early development of appetite control, Lancet 1:779.PubMedGoogle Scholar
  110. 109.
    Bernai, J., and Richards, M. P. M., 1970, The effect of bottle and breast feeding on infant development, J. Psychosom. Res. 14:247.Google Scholar
  111. 110.
    Shulka, A., Forsyth, H. A., Anderson, C., et al., 1972, Infantile overnutrition in the first year of life: A field study in Dudly Worcestershire, Br. Med. J. 2:507.Google Scholar
  112. 111.
    Fomon, S. J., Filer, L. J., Anderson, Y. A., et al., 1979, Recommendation for feeding normal infants, Pediatrics 63:52.PubMedGoogle Scholar
  113. 112.
    DeLuise, M., Blackburn, G. L., and Flier, J. S., 1980, Reduced activity of the red-cell sodium-potassium pump in human obesity, N. Engl. J. Med. 303:1017.Google Scholar
  114. 113.
    Whittam, R., and Blond, D. M., 1965, Respiratory control by an adenosine triphosphatase involved in active transport in brain cortex, Biochem. J. 92:147.Google Scholar
  115. 114.
    Bray, G. A., Kral, J. G., and Björntorp, P., 1981, Hepatic sodium-potassium-dependent ATPase in obesity, N. Engl. J. Med. 304:1580.PubMedGoogle Scholar

Copyright information

© Aubrey Milunsky, Emanuel A. Friedman, and Louis Gluck 1983

Authors and Affiliations

  • David P. Katz
    • 1
  • Kim I. Timmers
    • 1
  • Faith Winter
    • 1
  • Jerome L. Knittle
    • 1
  1. 1.Mount Sinai School of MedicineNew YorkUSA

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