Estrogen-Induced Uterine Hypertrophy
The mode of action of estrogen has been most studied in those tissues, such as the oviduct and the avian or amphibian liver, where its presence induces the synthesis of major secreted proteins. In the uterus, however, the effects of estrogens are not marked by the preferential synthesis of large quantities of a small number of proteins. Rather, the hormone induces an overall growth; a sequence of hypertrophy followed by hyperplasia which initiates the process whereby the tissue is prepared for a possible pregnancy. The entire growth process is characterized by a sequential stimulation of the synthesis of all classes of RNA, total protein, and DNA but the hypertrophic phase of the response appears to depend in large measure on the mobilization of existing ribosomes and the estrogen-induced synthesis of new ribosomes. This review summarizes our current knowledge of the events leading up to, and apparently prerequisite for, this activation process.
KeywordsEstrogen Administration rRNA Synthesis mRNA Population Polyadenylated mRNA Heterologous Hybridization
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