Stimulation of Milk-Fat Synthesis in Mammary Epithelioid Cells by Progesterone

  • Robert T. ChattertonJr.
  • Sheila M. Judge
  • Eldon D. Schriock
  • David Olive
  • John N. Haan
  • Harold G. Verhage
Part of the Biochemical Endocrinology book series (BIOEND)


While the mammary epithelium has a highly efficient mechanism for conversion of glucose to fatty acids, the metabolism of glucose is distinctly different from that occurring in adipose tissue. The pentose phosphate pathway predominates and glucose-6-phosphate dehydrogenase is much more sensitive to insulin (Leader and Barry, 1969; Oka et al., 1974). In adipose tissue glucose, lactate, and pyruvate serve equally well as precursors of fatty acids, but in rat mammary tissue lipogenesis from pyruvate is much less than that from glucose, and pyruvate nearly completely inhibits utilization of glucose for fatty acid synthesis (Katz et al., 1974). Also, the ratio of citrate cleavage enzyme to pyruvate carboxylase is very different, with mammary tissue having proportionally about five times more of the former. Cortisol acts particularly in the presence of some epinephrine to stimulate lipase activity and to inhibit transport of glucose in adipose tissue (Olefsky, 1975), but cortisol is required for lactation (Chatterton et al., 1979) and together with prolactin synergizes with insulin to stimulate lipogenesis in mammary tissue (Cameron et al., 1975). However, no direct evidence is available on the effect of cortisol on triglyceride turnover or lipase activity in mammary tissue.


Mammary Gland Mammary Tissue Fatty Acid Synthesis Human Breast Cancer Cell Line Mammary Epithelium 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Robert T. ChattertonJr.
    • 1
  • Sheila M. Judge
    • 1
  • Eldon D. Schriock
    • 1
  • David Olive
    • 1
  • John N. Haan
    • 1
  • Harold G. Verhage
    • 2
  1. 1.Department of Obstetrics and GynecologyNorthwestern University Medical SchoolChicagoUSA
  2. 2.Department of Obstetrics and GynecologyUniversity of Illinois at the Medical CenterChicagoUSA

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