The Estrogen-Induced/Dependent Renal Adenocarcinoma of the Syrian Hamster

  • Paul H. Naylor
  • Rabinder N. Kurl
  • Janet M. Loring
  • Claude A. Villee
Part of the Biochemical Endocrinology book series (BIOEND)


The events that occur in a tissue prior to a detectable malignant transformation are complex, and may be unique for each type of tumor. Alternatively, a wide variety of neoplasias may have many preneoplastic events in common. The several hormone-dependent tumors make up one class of neoplasms which may have similar molecular events resulting in their induction and growth. Following long-term estrogen treatment the Syrian hamster develops renal adenocarcinomas which are both estrogen-induced and estrogen-dependent (Kirkman, 1959). We have been using this model to find answers for several questions concerning the induction and growth of hormone-dependent tumors with emphasis on the role of estrogen at the molecular level.


Renal Tumor Syrian Hamster Golden Hamster Intermediate Lobe Estradiol Benzoate 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Paul H. Naylor
    • 1
  • Rabinder N. Kurl
    • 1
  • Janet M. Loring
    • 1
  • Claude A. Villee
    • 1
  1. 1.Department of Biological Chemistry and Laboratory of Human Reproduction and Reproductive BiologyHarvard Medical SchoolBostonUSA

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