The Estrogen-Induced/Dependent Renal Adenocarcinoma of the Syrian Hamster
The events that occur in a tissue prior to a detectable malignant transformation are complex, and may be unique for each type of tumor. Alternatively, a wide variety of neoplasias may have many preneoplastic events in common. The several hormone-dependent tumors make up one class of neoplasms which may have similar molecular events resulting in their induction and growth. Following long-term estrogen treatment the Syrian hamster develops renal adenocarcinomas which are both estrogen-induced and estrogen-dependent (Kirkman, 1959). We have been using this model to find answers for several questions concerning the induction and growth of hormone-dependent tumors with emphasis on the role of estrogen at the molecular level.
KeywordsRenal Tumor Syrian Hamster Golden Hamster Intermediate Lobe Estradiol Benzoate
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- Arafah, B. M., Marini, A., and Pearson, O. H., 1980, Effect of hypophysectomy and hormone replacement on hormone receptor levels and the growth of 7,12-dimethylbenz(a)anthraceneinduced mammary tumors in the rat, Endocrinology 107:1364.Google Scholar
- Dannies, P. S., Gautvik, R. M., and Tashjian, A. H., Jr., 1976, A possible role of cyclic AMP in mediating the effects of thyrotropin-releasing hormone in prolactin release and in prolactin and growth hormone synthesis in pituitary cells in culture, Endocrinology 98: 1147.PubMedCrossRefGoogle Scholar
- Hamilton, J. M. Saluja, P. G., Thody, A. J., and Flask, A., 1979, The pars intermedia and renal carcinogenesis in hamsters, Eur. J. Cancer 13: 29.Google Scholar
- Hogan, T. F., 1979, Hormonal therapy of renal-cell carcinoma, in: Endocrinology of Cancer, Vol. II ( D. P. Rose, ed.), p. 69, CRC Press, Bogata, Florida.Google Scholar
- King, R. J. B., and Mainwaring, W. I. P., 1974, Steroid—Cell Interactions, Butterworths, London. Kirkman, H., 1950, Different types of tumors observed in treated and in untreated golden hamsters, Anat. Rec. 106: 277.Google Scholar
- Kirkman, H., 1959, Estrogen-induced tumors of the kidney in Syrian hamsters, Natl. Cancer Inst. Monogr. 1: 1.Google Scholar
- Koneff, A. A., Simpson, M. E., and Evans, H. M., 1946, Effects of chronic administration of diethylstilboestrol on the pituitary and other endocrine organs of the hamster, Anat. Rec. 94: 169.Google Scholar
- Li, J. J., Li, S. A., Klein, L. A., and Villee, C. A., 1975, Dehydrogenase isozymes in the hamster and human renal adenocarcinoma, in: Isozyme, Vol. III ( C. L. Markert, ed.) p. 837, Academic Press, New York.Google Scholar
- Lin, Y. C., Talley, D. J., and Villee, C. A., 1978, Progesterone receptor levels in estrogen-induced renal carcinomas after serial passage beneath the renal capsule of Syrian hamsters, Cancer Res. 28: 1286.Google Scholar
- Matthews, V. S., Kirkman, H., and Bacon, R. L., 1947, Kidney damage in the Golden hamster following chronic administration of diethylstilbestrol and sesame oil, Proc. Soc. Exp. Med. 66: 195.Google Scholar
- Russfield, A. B., 1963, Effect of castration on induction of pituitary tumors with diethylstilbestrol in the Syrian hamster, Proc. Am. Assoc. Cancer Res. 4: 59.Google Scholar
- Saluja, P. G., Hamilton, J. M., Thody, A. J., Isnail, A. A., and Knowles, J., 1979, Ultrastructure of intermediate lobe of the pituitary and melanocyte-stimulating hormone secretion in oestrogen-induced kidney tumors in male hamsters, Arch. Toxicol. Suppl. 2: 41.Google Scholar