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Modulation of an Estrogen-Induced Protein in the MCF7 Human Mammary Cancer Cell

  • Chapter
Regulation of Gene Expression by Hormones

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Estrogens are able to induce two series of responses in a given target tissue. First, they increase cell proliferation and stimulate the general metabolism of the cells by favoring their entry into an active G1 step of the cell cycle (pleiotypic effect) (Herschko et al., 1971). Secondly, they stimulate the biosynthesis of specific proteins. The mechanism of the pleiotypic effect is poorly understood and may involve common intermediary steps between the binding of the receptor in the nucleus and the final responses. In any case, this pleiotypic effect can also be triggered by other hormones and is therefore not specific for estrogens.

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Author information

Authors and Affiliations

  1. Unité d’Endocrinologie Cellulaire et Moléculaire, U 148 INSERM, 34100, Montpellier, France

    Henri Rochefort

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  1. Henri Rochefort
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Editors and Affiliations

  1. International Foundation of Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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© 1983 Plenum Press, New York

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Rochefort, H. (1983). Modulation of an Estrogen-Induced Protein in the MCF7 Human Mammary Cancer Cell. In: McKerns, K.W. (eds) Regulation of Gene Expression by Hormones. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4418-6_2

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  • DOI: https://doi.org/10.1007/978-1-4684-4418-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4420-9

  • Online ISBN: 978-1-4684-4418-6

  • eBook Packages: Springer Book Archive

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