Modulation of an Estrogen-Induced Protein in the MCF7 Human Mammary Cancer Cell

  • Henri Rochefort
Part of the Biochemical Endocrinology book series (BIOEND)


Estrogens are able to induce two series of responses in a given target tissue. First, they increase cell proliferation and stimulate the general metabolism of the cells by favoring their entry into an active G1 step of the cell cycle (pleiotypic effect) (Herschko et al., 1971). Secondly, they stimulate the biosynthesis of specific proteins. The mechanism of the pleiotypic effect is poorly understood and may involve common intermediary steps between the binding of the receptor in the nucleus and the final responses. In any case, this pleiotypic effect can also be triggered by other hormones and is therefore not specific for estrogens.


Estrogen Receptor MCF7 Cell Human Breast Cancer Cell Line MCF7 Human Breast Cancer Cell Estrogen Receptor Binding 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Henri Rochefort
    • 1
  1. 1.Unité d’Endocrinologie Cellulaire et MoléculaireU 148 INSERMMontpellierFrance

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