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Effects of Ovarian Steroid Hormones on the Brain and Hypophysis Receptor Modulation and Chromatin Binding

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Regulation of Gene Expression by Hormones

Part of the book series: Biochemical Endocrinology ((BIOEND))

Abstract

Progesterone plays a role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release in rodents. Estrogen-induced gonadotropin surges in female rats can be facilitated or inhibited by progesterone in the cycling rats (Everett, 1948; Zeilmaker, 1966; Brown-Grant et al., 1972; Brown-Grant and Naftolin, 1972), and also be mimicked in the estrogen-treated ovariectomized rats by administration of progesterone (Caligaris et al., 1971; Freeman et al., 1976; Goodman, 1978), and in estrogen-treated prepubertal female rats of 28 days of age (Attardi, 1981). The effects of progesterone on sexual behavior in estrogen-primed female rats are also well-demonstrated (Meyerson, 1972; Feder and Marrone, 1977).

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References

  • Anderson, J., Clark, J. H., and Peck, Jr. E. J., 1972, Oestrogen and nuclear binding sites. Determination of specific sites by 3H-oestradiol exchange, Biochem. J. 126: 561.

    PubMed  CAS  Google Scholar 

  • Attardi, B., 1981, Facilitation and inhibition of the estrogen induced luteinizing hormone surge in the part by progesterone: Effects on cytoplasmic and nuclear estrogen receptors in the hypothalamic preoptic area, pituitary, and uterus, Endocrinology 108: 1487.

    Article  PubMed  CAS  Google Scholar 

  • Brown-Grant, K., and Naftolin, F., 1972, Facilitation of luteinizing hormone secretion in the female rat by progesterone. J. Endocrinol. 53: 37.

    Article  PubMed  CAS  Google Scholar 

  • Brown-Grant, K., Corker, C. S., and Naftolin, F., 1972, Plasma and pituitary luteinizing hormone concentrations and peripheral plasma oestradiol concentration during early pregnancy and after the administration of progestational steroids in the rat, J. Endocrinol. 53: 31.

    Article  PubMed  CAS  Google Scholar 

  • Burton, K., 1956, A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid, Biochem. J. 62: 315.

    PubMed  CAS  Google Scholar 

  • Caligaris, L., Astrada, J. J., and Taleisnik, S., 1971, Biphasic effect of progesterone on the release of gonadotropin in rats, Endocrinology 89: 331.

    Article  PubMed  CAS  Google Scholar 

  • DeBold, J. F., Martin, J. V., and Whalen, R. E., 1976, The excitation and inhibition of sexual receptivity in female hamsters by progesterone: Time and dose relationships, neural localization and mechanisms of action, Endocrinology 99: 1519.

    Article  Google Scholar 

  • Everett, J. W., 1948, Progesterone and estrogen in the experimental control of ovulation time and other features of the estrous cycle in the rat, Endocrinology 43: 389.

    Article  PubMed  CAS  Google Scholar 

  • Feder, H. H., and Marrone, B. L., 1977, Progesterone: Its role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release, Ann. N. Y. Acad. Sci. 286: 331.

    Article  PubMed  CAS  Google Scholar 

  • Freeman, M. C., Dupke, K. C., and Croteau, C. M., 1976, Extinction of the estrogen-induced daily signal for LH release in the rat: A role for the proestrous surge of progesterone, Endocrinology 99: 223.

    Article  PubMed  CAS  Google Scholar 

  • Goodman, R. L., 1978, A quantitative analysis of the physiological role of estradiol and progesterone in the control of tonic and surge secretion of LH in the rat, Endocrinology 102: 142.

    Article  PubMed  CAS  Google Scholar 

  • Haug, E., 1979, Progesterone suppression of estrogen-stimulated prolactin secretion and estrogen receptor levels in rat pituitary cells, Endocrinology 104: 429.

    Article  PubMed  CAS  Google Scholar 

  • Hsueh, A. J. W., Peck, Jr. E. J., and Clark, J. H., 1976, Control of uterine estrogen receptor levels by progesterone, Endocrinology 98: 438.

    Article  PubMed  CAS  Google Scholar 

  • Kato, J., 1978, Brain receptors for sex steroid hormones and their characterization and functional implications, in: Brain Endocrine Interaction III. Neural Hormones and Reproduction ( D. E. Scott, G. P. Kozlowski, F. Collins, and A. Weindl, eds.), pp. 287–301, Karger, Basel.

    Google Scholar 

  • Kato, J., and Onouchi, T., 1977, Specific progesterone receptors in the hypothalamus and anterior hypophysis of the rat, Endocrinology 10: 920.

    Article  Google Scholar 

  • Kato, J., and Onouchi, T., 1979, Nuclear progesterone receptors and characterization of cytosol receptors in the rat hypothalamus and anterior hypophysis, J. Steroid Biochem. 11: 845.

    Article  PubMed  CAS  Google Scholar 

  • Kato, J., and Villee, C. A., 1967, Preferential uptake of estradiol by the anterior hypothalamus of the rat, Endocrinology 80: 567.

    Article  PubMed  CAS  Google Scholar 

  • Kato, J., Onouchi, T., and Okinaga, S., 1978, Hypothalamic and hypophysial progesterone receptors: Estrogen priming effect, localization and isolation of nuclear receptors, J. Steroid Biochem. 9: 415.

    Google Scholar 

  • Katzenellenbogen, J. A., Johnson, Jr. H. J., and Carlson, K. E., 1973, Studies on the uterine cytoplasmic estrogen binding protein. Thermal stability and ligand dissociation rate. An assay of empty and filled sites by exchange, Biochemistry 12: 4092.

    Article  PubMed  CAS  Google Scholar 

  • Korenman, S. G., and Dukes, B. A., 1970, Specific estrogen binding by the cytoplasm of human breast carcinoma, J. Clin. Endocrinol. Metab. 30: 639.

    Google Scholar 

  • Lisk, R. D., and Reuter, L. A., 1977, In vivo progesterone treatment enhances [3H]estradiol retention by neural tissue of the female rat, Endocrinology 100: 1652.

    Article  PubMed  CAS  Google Scholar 

  • Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem. 193: 265.

    PubMed  CAS  Google Scholar 

  • MacLusky, N. J., and McEwen, B. S., 1978, Oestrogen modulates progestin receptor concentrations in some rat brain regions but not in others, Nature 274: 276.

    Article  PubMed  CAS  Google Scholar 

  • Marrone, B. L., and Feder, H. H., 1977, Characteristics of [3H]estrogen and [3H]progestin uptake and effects of progesterone on [3H]estrogen uptake in brain anterior pituitary and peripheral tissues of male and female guinea pigs, Biol. Reprod. 17: 42.

    Article  CAS  Google Scholar 

  • McGuire, W. L., 1975, Quantitation of estrogen receptors in mammary carcinoma, in: Methods in Enzymology, vol. 36: Hormone Action ( B. W. O’Malley and J. G. Hardman, eds.), pp. 248–254, Academic Press, New York.

    Google Scholar 

  • Meyerson, B., 1972, Latency between intravenous injection of progestins and the appearance of estrous behavior in estrogen-treated ovariectomized rats, Horm. Behay. 3: 1.

    Article  CAS  Google Scholar 

  • Moguilewsky, M., and Raynaud, J-P., 1979, The relevance of hypothalamic and hypophyseal progestin receptor regulation in the induction and inhibition of sexual behavior in the female rat, Endocrinology 105: 516.

    Article  PubMed  CAS  Google Scholar 

  • Notides, A. G., 1970, Binding affinity and specificity of the estrogen receptor of the rat uterus and anterior pituitary, Endocrinology 87: 987.

    Article  PubMed  CAS  Google Scholar 

  • O’Malley, B. W., Schrader, W. T., and Spelsberg, T. C., 1973, Receptor interactions with the genome of eucaryotic target cells, in: Receptors for Reproductive Hormones ( B. W. O’Malley and A. Means, eds.), pp. 174–196, Plenum Press, New York.

    Chapter  Google Scholar 

  • Pavlik, E. J., and Coulson, P. B., 1976, Modulation of estrogen receptors in four different target tissues: Differential effects of estrogen vs. progesterone, J. Steroid Biochem. 7: 369.

    Article  PubMed  CAS  Google Scholar 

  • Reuter, L. A., and Lisk, R. D., 1976, Progesterone may act at hypothalamus and pituitary by way of enhancement of oestrogen retention, Nature 262: 790.

    Article  PubMed  CAS  Google Scholar 

  • Scatchard, G., 1949, The attractions of proteins for small molecules and ions, Ann. N.Y. Acad. Sci. 51: 660.

    Article  CAS  Google Scholar 

  • Schwartz, S. M., Blaustein, J. D., and Wade, G. N., 1979, Inhibition of estrous behavior by progesterone in rats: Role of neural estrogen and progestin receptors, Endocrinology 105: 1078.

    Article  PubMed  CAS  Google Scholar 

  • Shaw, L. M. J., and Huang, R. C., 1970, A description of two procedures which avoid the use of extreme pH conditions for the resolution of components isolated from chromatins prepared from pig cerebellar and pituitary nuclei, Biochemistry 9: 4530.

    Article  PubMed  CAS  Google Scholar 

  • Spelsberg, T. C., Steggles, A. W., and O’Malley, B. W., 1971, Progesterone binding components of chick oviduct, J. Biol. Chem. 246: 4188.

    Google Scholar 

  • Talley, D., Li, J. J., Li, S., and Villee, C. A., 1975, Biochemical comparison of estrogen receptors of the hamster hypothalamus and uterus, Endocrinology 96: 1135.

    Article  PubMed  CAS  Google Scholar 

  • Zeilmaker, G. H., 1966, The biphasic effect of progesterone on ovulation in the rat, Acta Endocrinol. 51: 461.

    PubMed  CAS  Google Scholar 

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© 1983 Plenum Press, New York

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Kato, J., Onouchi, T. (1983). Effects of Ovarian Steroid Hormones on the Brain and Hypophysis Receptor Modulation and Chromatin Binding. In: McKerns, K.W. (eds) Regulation of Gene Expression by Hormones. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4418-6_11

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  • DOI: https://doi.org/10.1007/978-1-4684-4418-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4420-9

  • Online ISBN: 978-1-4684-4418-6

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