Effects of Ovarian Steroid Hormones on the Brain and Hypophysis Receptor Modulation and Chromatin Binding
Progesterone plays a role in the central nervous system as a facilitator and inhibitor of sexual behavior and gonadotropin release in rodents. Estrogen-induced gonadotropin surges in female rats can be facilitated or inhibited by progesterone in the cycling rats (Everett, 1948; Zeilmaker, 1966; Brown-Grant et al., 1972; Brown-Grant and Naftolin, 1972), and also be mimicked in the estrogen-treated ovariectomized rats by administration of progesterone (Caligaris et al., 1971; Freeman et al., 1976; Goodman, 1978), and in estrogen-treated prepubertal female rats of 28 days of age (Attardi, 1981). The effects of progesterone on sexual behavior in estrogen-primed female rats are also well-demonstrated (Meyerson, 1972; Feder and Marrone, 1977).
KeywordsEstrogen Receptor Progesterone Receptor Luteinizing Hormone Ovarian Steroid Luteinizing Hormone Surge
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