Hormone Action in Human Breast Cancer Estrogen Regulation of Specific Proteins

  • David J. Adams
  • Dean P. Edwards
  • William L. McGuire
Part of the Biochemical Endocrinology book series (BIOEND)


How do estrogens regulate mammary tumor growth and function? Researchers have been pondering this question ever since breast tumor regression was reported in premenopausal patients following oophorectomy (Beatson, 1896). However, systematic exploitation of endocrine ablative surgery did not occur until the 1950s when Huggins and Dao (1954) obtained 38 clinical remissions after performing 100 ovariectomies for palliation of advanced breast cancer. A similar result occurred with adrenalectomy (Huggins and Bergenstal, 1952) and patients responding to this surgery were found to concentrate [3H]hexestrol in their metastases (Folca et al., 1961). Jensen et al. (1967) and Terenius (1968) then observed that the clinical response to endocrine therapy was correlated with specific binding of estradiol by certain human breast tumor biopsy specimens. This observation and the discovery of a high-affinity receptor protein for estradiol in the cytoplasm of target cells (loft and Gorski, 1966) led to the widespread use of an estrogen receptor (ER) assay to identify hormone-responsive breast tumors (McGuire et al., 1975). Subsequent studies have shown that approximately two-thirds of all breast tumor biopsy specimens contain estrogen receptors, and, of these tumors, that about half respond to ablative and additive endocrine therapies (Edwards et al., 1979). Furthermore, ER analysis of the primary tumor can predict response to endocrine therapy if inaccessible metastatic disease develops.


Estrogen Receptor Breast Tumor Progesterone Receptor Estrogen Action Human Breast Cancer Cell Line 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • David J. Adams
    • 1
  • Dean P. Edwards
    • 1
  • William L. McGuire
    • 1
  1. 1.Department of MedicineUniversity of Texas Health Science CenterSan AntonioUSA

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