On the Central Dopaminergic Mechanisms for Motion and Emotion

  • E. Kafetzopoulos
Part of the NATO Advanced Science Institutes Series book series (NSSA, volume 56)


According to numerous authors (e.g., Iversen and Koob, 1977; Marshall and Teitelbaum, 1977) motivated activity is mediated by two dopaminergic pathways, the nigro-striatal and the mesolimbic. The nigro-striatal pathway originates from the dopaminergic cells of the pars compacta of the substantia nigra (SNc), known as cell group A9, and terminates in the corpus striatum. The mesolimbic pathway originates from the dopaminergic cells of the ventral tegmental area (VTA), known as cell group A10, and terminates in various structures of the limbic system, mainly in the nucleus accumbens septi (NAS) and the olfactory tubercle. It has been suggested that the nigro-striatal system, with its massive outputs to classic motor circuitries both at cortical and subcortical level, is involved in regulating the motor tone, preparing motor circuits for certain locomotor, postural and behavioral tasks. However, the nigro-striatal system initiates a motor act only when instructed to do so. Where is the brain system that “decides” which motor acts should be initiated?


Ventral Tegmental Area Limbic System Dopaminergic Cell Dopaminergic Activity Corpus Striatum 


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  1. Fonnum, F., Walaas, I., and Iversen, E., 1977, Localization of GABA-ergic, cholinergic and aminergic structures in the limbic system. J. Neurochem., 29:221–230.PubMedCrossRefGoogle Scholar
  2. Iversen, S.D., 1977, An overview of striatal function, in “Handbook of Psychopharmacology” Vol.8, L.L. Iversen, S.D. Iversen and S.H. Snyder, eds., Plenum Press, London, New York.CrossRefGoogle Scholar
  3. Iversen, S.D., and Koob, G.F., 1977, Behavioral implications of dopaminergic neurons in the mesolimbic system, in “Advances in Biochemical Psychopharmacology” Vol.16, E. Costa and G.L. Gessa, eds., Raven Press, New York.Google Scholar
  4. Künzle, E., 1975, Bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia: An autoradiographic study in Macaca fascicularis. Brain Res., 88:195–209.PubMedCrossRefGoogle Scholar
  5. Marshall, J.F., and Teitelbaum, P., 1977, New considerations in the neuropsychology of motivated behaviors, in “Handbook of Psychopharmacology” Vol.7, L.L. Iversen, S.D. Iversen and S.H. Snyder, eds., Plenum Press, London, New York.Google Scholar
  6. Nauta, W.J.H., and Domesick, V.B., 1978, Cross-roads of limbic and striatal circuitry: Hypothalamonigral connections, in “Limbic Mechanisms”, E. Livingston and O. Hornykiewicz, eds., Plenum Press, London, New York.Google Scholar
  7. Olianas, M.C., De Montis, G.M., Mulas, G., and Tagliamonte, A., 1978, The striatal dopaminergic activity is mediated by the inhibition of a nigral, non dopaminergic neuronal system via a strio-nigral GABA-ergic pathway. Eur. J. Pharmacol., 49:233–241.PubMedCrossRefGoogle Scholar
  8. Papadopoulos, G., and Huston, J.P., 1978, Behavioral effects of intranigral injections of GABA agonists and antagonists in the thalamic rat. Neurosci. Lett. Suppl., 1:262.Google Scholar
  9. Pycock, C.J., 1980, Turning behavior in animals. Neurosci., 5:461–514.CrossRefGoogle Scholar
  10. Reavill, C., Leich, P., and Marsden, C.D., 1979, Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway. Exp. Brain Res., 37:309–316.PubMedCrossRefGoogle Scholar
  11. Ricardo, J., 1980, Efferent connections of the subthalamic region in the rat I: The subthalamic nucleus of Luys. Brain Res., 202:257–271.PubMedCrossRefGoogle Scholar
  12. Scheel-Krüger, J., Arnt, J., Magelung, G., Olianas, M., Przewlocka, B., and Christensen, A.V., 1980, Behavioral functions of GABA in basal ganglia and limbic system. Brain Res. Bull., Suppl.2, 5:261–267.CrossRefGoogle Scholar
  13. Swanson, L.W., and Cowan, W.M., 1977, An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat. J. Comp. Neurol., 172:49–84.PubMedCrossRefGoogle Scholar
  14. Waddington, J.L., and Cross, A.K., 1978, Neurochemical changes following kainic acid lesions of the nucleus accumbens: Implications for a GABAergic accumbal-ventral tegmental pathway. Life Sci., 22:1011–1014.PubMedCrossRefGoogle Scholar
  15. Yehuda, S., and Frommer, R., 1977, The possible role of dopamine in phenothiazine-induced hypothermia in rats: An application to DA hypothesis of schizophrenia. Int. J. Neurosci., 7:67–72.PubMedCrossRefGoogle Scholar
  16. York, D.H., and Faber, J.E., 1977, An electrophysiological study of the nigro-tectal relationships: A possible role in turning behavior. Brain Res., 120:383–386.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • E. Kafetzopoulos
    • 1
  1. 1.Department of Experimental Pharmacology School of MedicineUniversity of AthensAthensGreece

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