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Intra-Abdominal Applications of Hematoporphyrin Photoradiation Therapy

  • H. O. DouglassJr.
  • H. R. Nava
  • K. R. Weishaupt
  • D. Boyle
  • M. G. Sugerman
  • E. Halpern
  • T. J. Dougherty
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)

Abstract

At Roswell Park Memorial Institute (RPMI), long experience in the management of tumors with hematoporphyrin derivative (HPD) photoradiation therapy (PRT) has documented the destruction of a wide range of neoplasms with remarkable regularity (1,2). The surrounding inflammatory response and eschar that formed at the site of the tumor nodule indicated that some damage to normal adjacent tissue occurred. In an attempt to evaluate the potential for HPD PRT in the abdomen, we carried out preclinical trial of the tolerance of normal intra-abdominal viscera, and of that containing an implanted Brown-Pearce tumor, in rabbits. For an assay in a primate system, three baboons were studied. Lessons learned from animal trials have recently been applied toward the management of intra-abdominal human neoplasia.

Keywords

Primate System Roswell Park Memorial Institute Hematoporphyrin Derivative Full Thickness Necrosis Photoradiation Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Dougherty, T.J., Kaufman, J.E., Goldfarb, A., Weishaupt, K.R., Boyle, D., and Mittelman, A. Photoradiation Therapy for the Treatment of Malignant Tumor. Cancer Res.38:2628–2635, 1978.PubMedGoogle Scholar
  2. 2.
    Dougherty, T.J., Gomer, C.J., and Weishaupt, K.R. Ener-gentics and Efficiency of Photoinactivation of Murine Tumor Cells Containing Hematoporphyrin. Cancer Res.36:2330–2333, 1976.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • H. O. DouglassJr.
    • 1
  • H. R. Nava
    • 1
  • K. R. Weishaupt
    • 1
  • D. Boyle
    • 1
  • M. G. Sugerman
    • 1
  • E. Halpern
    • 1
  • T. J. Dougherty
    • 1
  1. 1.Roswell Park Memorial InstituteBuffaloUSA

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