HPD — A Study of Its Components and Their Properties
The phototoxic effect (“photodynamic action”) of administered porphyrin in mammals appears to have been first observed by Hausmann (1) in mice and by Meyer-Betz (2) in man. The effect was known in certain porphyrias long before this, but the cause was not known. The localisation of administered porphyrins in tumour tissue was recognised (3) in the 1940s, and this behaviour was explored further in the 1950s in work that led to the development of the HPD preparation (4,5). It was not until 1972 that these two ideas concerning the biological activity of porphyrins (that is, photode-gradation of tissue and localisation in tumours) came together successfully, when Diamond and his colleagues (6) demonstrated that a porphyrin could be used to photosen-sitise the preferential degradation of tumour implants in the rat. In 1975 this result was confirmed and extended by Berenbaum and his colleagues (7), and by Dougherty and his colleagues (8).
KeywordsDimethyl Sulphoxide Evans Blue Dimethyl Ester Preparative Separation Photodynamic Action
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- 1.W. Hausmann, Biochem. Z., 1911, 30, 276.Google Scholar
- 2.F. Meyer-Betz, Deutsch. Arch. Klin. Med., 1913, 112, 476.Google Scholar
- 3a.F.H.J. Figge, G.S. Weiland, and L.O. Manganiello, Proc. Soc. Exp. Biol. Med., 1948, 64, 640.Google Scholar
- 4.S. Schwartz, K. Absolon, and H. Vermund, Univ. Minnesota Med. Bull., 1955, 27, 7.Google Scholar
- 10.R. Bonnett, R.J. Ridge, P.A. Scourides, and M.C. Berenbaum, J. Chem. Soc. Chem. Comm., 1980, 1198.Google Scholar
- 11.R. Bonnett, R.J. Ridge, P.A. Scourides, and M.C. Berenbaum, J. Chem. Soc. Perkin Trans I, 1981, 3135.Google Scholar
- 15.M.C. Berenbaum, R. Bonnett, R.J. Ridge, and P.A. Scourides, Abstracts, Tetrapyrrole Discussion Group, Glasgow, September 26th 1980.Google Scholar
- 16.M.C. Berenbaum, R. Bonnett, and P.A. Scourides, Br. J. Cancer, 1982, In Press.Google Scholar
- 17.R. Bonnett, C.R. Lambert, E.J. Land, P.A. Scourides, R.S. Sinclair, and T.G. Truscott, in preparation.Google Scholar