Skip to main content
SpringerLink
Log in

Photodynamic Membrane Damage

  • Chapter
Book cover Porphyrin Photosensitization

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 160))

Abstract

The use of porphyrins in photochemotherapy of neoplastic disease is based on the formation of singlet oxygen (Spikes, 1975; Weishaupt et al., 1976; Kessel, 1981) and possibly hydroxyl radicals (Hariharan et al., 1980), subsequent to photoactivation of the sensitizer. The mechanism of cell killing is still unknown. Many studies indicate that membrane and DNA damage are involved, but the relative contribution of these processes to cell inactivation is still a matter of dispute.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. De Goeij, A.F.P.M., P.H.J.T. Ververgaert and J. van Steveninck, 1975. Photodynamic effects of protoporphyrin on the architecture of erythrocyte membranes in protoporphyria and in normal red blood cells. Clin. Chim. Acta 62:287–292.

    Article  PubMed  Google Scholar 

  2. De Goeij, A.F.P.M. and J. van Steveninck, 1976. Photodynamic effects of protoporphyrin on cholesterol and unsaturated fatty acids in erythrocyte membranes in protoporphyria and in normal red blood cells. Clin. Chim. Acta 68:115–122.

    Article  PubMed  Google Scholar 

  3. De Goeij, A.F.P.M., R.J.C. van Straalen and J. van Steveninck, 1976. Photodynamic modification of proteins in human red blood cell membranes, induced by protoporphyrin. Clin. Chim. Acta 71:485–494.

    Article  PubMed  Google Scholar 

  4. Doleiden, F.H., S.R. Fahrenholtz, A.A. Lamola and A.M. Trozzolo, 1974. Reactivity of cholesterol and some fatty acids toward singlet oxygen. Photochem. Photobiol. 20:519–521.

    Article  PubMed  CAS  Google Scholar 

  5. Dubbelman, T.M.A.R., A.W. de Bruijne and J. van Steveninck, 1977. Photodynamic effects of protoporphyrin on red blood cell deformability. Biochem. Biophys. Res. Commun. 77:811–817.

    Article  PubMed  CAS  Google Scholar 

  6. Dubbelman, T.M.A.R., A.F.P.M. de Goeij and J. van Steveninck, 1978a. Photodynamic effects of protoporphyrin on human erythrocytes. Biochim. Biophys. Acta 511:141–151.

    Article  CAS  Google Scholar 

  7. Dubbelman, T.M.A.R., A.F.P.M. de Goeij and J. van Steveninck, 1978b. Protoporphyrin-sensitized photodynamic modification of proteins in isolated human red blood cell membranes. Photochem. Photobiol. 28:197–204.

    Article  CAS  Google Scholar 

  8. Dubbelman, T.M.A.R., C. Haasnoot and J. van Steveninck, 1980a. Temperature dependence of photodynamic red cell membrane damage. Biochim. Biophys. Acta601:220–227.

    Article  CAS  Google Scholar 

  9. Dubbelman, T.M.A.R., A.F.P.M. de Goeij and J. van Steveninck, 1980b. Protoporphyrin-induced photodynamic effects on transport processes across the membrane of human erythrocytes. Biochim. Biophys.Acta 595:133–139.

    Article  CAS  Google Scholar 

  10. Dubbelman, T.M.A.R., A.F.P.M. de Goeij, K. Christianse and J. van Steveninck, 1981. Protoporphyrin-induced photodynamic effects on band 3 protein of human erythrocyte membranes. Biochim. Biophys. Acta 649: 310–316.

    Article  PubMed  CAS  Google Scholar 

  11. Fischer, T.M., C.W.M. Haest, M. Stöhr, D. Kamp and B. Deuticke, 1978. Selective alteration of erythrocyte deformability by SH-reagents. Evidence for an involvement of spectrin in membrane shear elasticity. Biochim. Biophys. Acta 510:270–282.

    Article  PubMed  CAS  Google Scholar 

  12. Girotti, A.W., 1975. Photodynamic action of bilirubin on human erythrocyte membranes. Modification of polypeptide constituents. Biochem. 14:3377–3383.

    Article  CAS  Google Scholar 

  13. Girotti A.W., S. Lyman and M.R. Deziel, 1979. Methylene blue-sensitized photooxidation of hemoglobin: evidence for cross-link formation. Photochem.Photobiol. 29:1119–1125.

    Article  PubMed  CAS  Google Scholar 

  14. Girotti, A.W., 1980. Photosensitized cross-linking of erythrocyte membrane proteins. Biochim. Biophys. Acta 602:45–56.

    Article  PubMed  CAS  Google Scholar 

  15. Hariharan, P.V., J. Courtney and S. Eleczko, 1980. Production of hydroxyl radicals in cell systems exposed to haematoporphyrin and red light. Int. J. Radiat. Biol. 32:691–694.

    Google Scholar 

  16. Jennings, M.L. and H. Passow, 1979. Anion transport across the erythrocyte membrane, in situ proteolysis of band 3 protein and cross-linking of proteolytic fragments by 4,4’-diisothiocyano dihydrostilbene-2,2’-disulfonate. Biochim. Biophys. Acta 554:498–519.

    Article  PubMed  CAS  Google Scholar 

  17. Kessel, D., 1977. Effects of photoactiviated porphyrins at the cell surface of leukemia L1210 cells. Biochem. 16:3443–3449.

    Article  CAS  Google Scholar 

  18. Kessel, D., 1981. Transport and binding of hematopor-phyrin derivative and related porphyrins by Murine Leukemia L1210 cells. Cancer Res. 41:1318–1323.

    PubMed  CAS  Google Scholar 

  19. Lepke, S., H. Fasold, M. Pring and H. Passow, 1976. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of DIDS and H2DIDS. J. Membrane Biol. 29:147–177.

    Article  CAS  Google Scholar 

  20. Marchesi, V.T. 1979. Spectrin: present status of a putative cyto-skeletal Protein of the red cell membrane. J. Membrane Biol. 51:101–131.

    Article  CAS  Google Scholar 

  21. Ramjeesingh, M., A. Gaarn and A. Rothstein, 1980. The location of a disulfonic stilbene binding site in band 3, the anion transport protein of the red blood cell membrane. Biochim. Biophys. Acta 599:127–139.

    Article  PubMed  CAS  Google Scholar 

  22. Ramjeesingh, M., A. Gaarn and A. Rothstein, 1981. The amino acid conjugate formed by the interaction of the anion transport inhibitor 4,4’-diisothiocyano-2,2’-stilbenedisulfonic acid with band 3 protein from human red blood cell membranes. Biochim. Biophys. Acta 641:173–182.

    Article  PubMed  CAS  Google Scholar 

  23. Schothorst, A.A., J. van Steveninck, L.N. Went and D. Suurmond, 1970. Protoporphyrin-induced photohemoly-sis in protoporphyria and in normal red blood cells. Clin. Chim. Acta 28:41–49.

    Article  PubMed  CAS  Google Scholar 

  24. Spector, M., S. O’Neal and E. Racker, 1980. Reconstitution of the Na+K+ pump of Ehrlich Ascites Tumor and enhancement of efficiency by quercetin. J. Biol. Chem. 255:5504–5507.

    PubMed  CAS  Google Scholar 

  25. Spikes, J.D., 1975. Porphyrins and related compounds as photodynamic sensitizers. Ann. N. Y. Acad. Sci. 244:496–508.

    Article  PubMed  CAS  Google Scholar 

  26. Straight, R. and J.D. Spikes, 1978. Sensitized photo-oxidation of amino acids: effects on the reactivity of their primary amino groups with fluorescamine and o-phthalaldehyde. Photochem. Photobiol. 27:565–569.

    Article  CAS  Google Scholar 

  27. Tomita, M., M. Irie and T. Ukita, 1969. Sensitized photooxidation of histidine and its derivatives. Products and mechanism of the reaction. Biochem. 8: 5149–5160.

    Article  CAS  Google Scholar 

  28. Verweij, H., T.M.A.R. Dubbelman and J. van Steveninck, 1981. Photodynamic protein cross-linking. Biochim. Biophys. Acta 647:87–94.

    Article  PubMed  CAS  Google Scholar 

  29. Verweij, H. and J. van Steveninck, 1981. Model studies on photodynamic cross-linking. Photochem. Photobiol., 35:265–267.

    Article  Google Scholar 

  30. Weishaupt, K.R., C.J. Gomer and T.J. Dougherty, 1976. Identification of singlet oxygen as the cytotoxic agent in photodestruction of a murine tumor. Cancer Res. 36: 2326–2329.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sylvius Laboratories, Department of Medical Biochemistry, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands

    J. van Steveninck, T. M. A. R. Dubbelman & H. Verweij

Authors
  1. J. van Steveninck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. M. A. R. Dubbelman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Verweij
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    David Kessel

  2. Roswell Park Memorial Institute, Buffalo, New York, USA

    Thomas J. Dougherty

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

van Steveninck, J., Dubbelman, T.M.A.R., Verweij, H. (1983). Photodynamic Membrane Damage. In: Kessel, D., Dougherty, T.J. (eds) Porphyrin Photosensitization. Advances in Experimental Medicine and Biology, vol 160. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4406-3_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-4406-3_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4408-7

  • Online ISBN: 978-1-4684-4406-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation