Photodynamic Membrane Damage

  • J. van Steveninck
  • T. M. A. R. Dubbelman
  • H. Verweij
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)


The use of porphyrins in photochemotherapy of neoplastic disease is based on the formation of singlet oxygen (Spikes, 1975; Weishaupt et al., 1976; Kessel, 1981) and possibly hydroxyl radicals (Hariharan et al., 1980), subsequent to photoactivation of the sensitizer. The mechanism of cell killing is still unknown. Many studies indicate that membrane and DNA damage are involved, but the relative contribution of these processes to cell inactivation is still a matter of dispute.


Erythrocyte Membrane Anion Transport Disulfonic Acid Cell Deformability Human Erythrocyte Membrane 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • J. van Steveninck
    • 1
  • T. M. A. R. Dubbelman
    • 1
  • H. Verweij
    • 1
  1. 1.Sylvius LaboratoriesDepartment of Medical BiochemistryLeidenThe Netherlands

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