Photoradiation Therapy — Clinical and Drug Advances
Photoradiation therapy (PRT) using hematoporphyrin derivative (HPD1) as photosensitizer is becoming widely investigated by many groups in the U.S. and abroad for a variety of malignancies. At Roswell Park, while most of our reported data deals with treatment of cutaneous and subcutaneous lesions, largely in patients with advanced disease, we are increasingly investigating PRT for other types of lesions. Elsewhere in this volume, our studies on endoscopic PRT for lung and tracheal lesions will be described by Dr. Vincent, and studies of esophageal tumors by Dr. Douglass. In addition we are carrying out treatment of brain tumors with Dr. West and head and neck tumors with Drs. Shedd, Sako and Raczak. In addition, we will be reporting on several basic studies regarding the active component of HPD as well as uptake and retention studies of HPD in vitro (Henderson, Bellnier).
KeywordsInflammatory Breast Cancer Exclusion Limit Light Dose Hematoporphyrin Derivative Tracheal Lesion
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