Hematoporphyrin Derivative: Chemical Composition, Photochemical and Photosensitizing Properties
“Hematoporphyrin derivative” (HPD) is a product prepared by treating acetylated hematoporphyrin (HPA) with alkali. Acetylated hematoporphyrin is prepared by treating hematoporphyrin dihydrochloride with a mixture of sulphuric acid and acetic acid (Lipson et al. 1961). HPD has been reported by a number of investigators to be preferentially retained in tumors (for a review, see Moan and Christensen, 1980). HPD is now being evaluated for use in cancer detection and therapy. The therapeutic aspect is based on the fact that many porphyrins are efficient photosensitizers. Tumor tissue, which after injection contains more HPD than surrounding tissue, is selectively destroyed when exposed to visible light (Dougherty et al., 1975).
KeywordsQuantum Yield Singlet Oxygen Fluorescence Quantum Yield Alkali Treatment Acetate Group
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