Photobiologic Considerations in Photoradiation Therapy

  • John A. Parrish
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 160)


Hematoporphyrin derivative (HPD) photoradiation therapy of tumors depends on selective cell injury. The major selectivity of the treatment rests on an increased amount or prolonged retention of certain constituents or biotransformation products of HPD in tumor tissues. This increased concentration or prolonged retention results from some incompletely understood biochemical properties of malignant cells (protein binding, membrane changes, aberrant biotransformation) or cancer tissue (increased blood supply, avascular zones, absent lymphatics). Identification of the most active components of HPD and a better understanding of the mechanisms of prolonged retention may permit improved treatment design to achieve more selective destruction of tumor tissue.


Stratum Corneum Regular Reflectance Prolonged Retention Near Infrared Radiation Hematoporphyrin Derivative 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John A. Parrish
    • 1
  1. 1.Department of Dermatology, Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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