Rapid, Non-Invasive Determination of Cardiac Output at Rest by CO2 Rebreathing Using a Computerized System: Application in Normal Adults and Patients with Cardiac Disease

  • Donald A. Mahler
  • Richard A. Matthay
  • Peter E. Snyder
  • Rene Langou
  • Barry L. Zaret
  • Jacob Loke


In 1909 Pleschl described an indirect method for measuring mixed venous carbon dioxide tension (\(P\bar{v}\) CO2). Application of this technique led to the development of non-invasive determination of cardiac output (CO) by carbon dioxide rebreathing (CO2RB). Clinical utilization of this method, however, has been limited because of technical considerations: expired gas must be collected and analyzed; and various calculations, including correction formulas, are necessary2,3.


Cardiac Output Forced Vital Capacity Metabolic Measurement Maximal Expiratory Flow Volume Carbon Dioxide Rebreathing 
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  1. 1.
    J. Plesch, Hemodynamische Studies, A Exp.Therap, 6: 380–618, 1909.Google Scholar
  2. 2.
    N.L. Jones, D.G. Robertson, and J.W. Kane, Difference between end-tidal and arterial PCO2 in exercise, J. Appl,. Physiol. 47: 954–960, 1979.Google Scholar
  3. 3.
    GJR McHardy, Relationship between the difference in pressure and content of carbon dioxide in arterial and venous blood, Clin, Sci, 32: 299–309, 1967.Google Scholar
  4. 4.
    P.F. Scholander, Analyzer for accurate estimation of respiratory gases in one-half cubic centimeter samples, J. Biol. Chem. 167: 235–249, 1947.Google Scholar
  5. 5.
    J.H. Comroe, Physiology of Respiration, Chicago: Year Book Medical Publishers Inc., 1974, p. 196.Google Scholar
  6. 6.
    C.R. Collier. Determination of mixed venous CO2 tension by rebreathing. J. Appl Physiol 9: 25–29, 1956.Google Scholar
  7. 7.
    N.L. Jones, E.J. M. Campbell, R.H.T. Edwards, and G. Wilkoff, Alveolar to blood PCO2 difference during rebreathing in exercise, J. Appl Physiol 27: 356–360, 1969.CrossRefGoogle Scholar
  8. 8.
    R.M. Gardner (Chairman). Report of snowbird workshop on standardization of spirometry, ATS News 3: 20–24, 1977.Google Scholar
  9. 9.
    J.F. Morris, A. Koski, and L.C. Johnson, Spirometric standards for healthy nonsmoking adults, Am Rev Respir Dis 103: 57–67, 1971.Google Scholar
  10. 10.
    N.W. Higgins, and J.B. Keller, Seven measures of ventilatory lung function, Am Rev Respir Dis 108: 258–272, 1973.Google Scholar
  11. 11.
    B.W. Brown, Jr., and N. Hollander, Statistics: A Biomedical Introduction, New York: John Wiley and Sons, 1977.Google Scholar
  12. 12.
    R.J. Ferguson, J.A. Faulkner, and S. Julius, et al, Comparison of cardiac output determined by CO2 rebreathing and dye-dilution methods. J Appl Physiol 25: 450–454, 1968.Google Scholar
  13. 13.
    G. Muiesan, C.A. Sorbini, and E. Solinas et al, Comparison of CO2-rebreathing and Fick methods of determining cardiac output, J. Appl Physiol 24: 424–429, 1968.Google Scholar
  14. 14.
    K. Klausen, Comparison of CO2 rebreathing and acetylene methods for cardiac output, J Appl Physiol 20: 763–766, 1965.Google Scholar
  15. 15.
    J.P. Clausen, O.A. Larsen, and J. Trap-Jensen, J. Cardiac output in middle-aged patients determined with CO2 rebreathing method, J Appl Physiol 28: 337–342, 1970.Google Scholar
  16. 16.
    J.A. Franciosa, Evaluation of the CO2 rebreathing cardiac output method in seriously ill patients, Circ 55: 449–455, 1977.Google Scholar
  17. 17.
    C.C. Davis, N.L. Jones, and B.J. Sealey, Measurements of cardiac output in seriously ill patients using a CO2 rebreathing method, Chest 73: 167–172, 1978.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Donald A. Mahler
    • 1
  • Richard A. Matthay
    • 1
  • Peter E. Snyder
    • 1
  • Rene Langou
    • 1
  • Barry L. Zaret
    • 1
  • Jacob Loke
    • 1
  1. 1.Pulmonary and Cardiology Sections Department of Internal MedicineYale University School of MedicineNew HavenUSA

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