Immediate Responses to Lung Irritants Detected by Automated Measurements of Airway Resistance and Partial Flow-Volume Curves

  • P. J. Rees
  • P. J. Chowienczyk
  • T. J. H. Clark


Automated measurements of specific conductance and partial flow-volume curves have allowed the detailed investigation of changes occurring in the first 30 seconds after inhalation of cigarette smoke. Smokers and non-smokers show transient airway narrowing which appears to be a nervously mediated reflex contraction of smooth muscle. The major part of the stimulus is produced by the particulate matter in the smoke.


Cigarette Smoke Airway Resistance Sodium Cromoglycate Total Lung Capacity Automate Measurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    H.L. Motley, N.J. Kuzman, Cigarette smoke, its effect on pulmonary function measurement, California Medicine 1958, 88: 211–220.Google Scholar
  2. 2.
    M. Reintjes, J. Swierenga, J.M. Bogaard, Effect of smoking one cigarette on airways resistance, Scand. J. Resp. Dis. 1972, 53: 129–134.Google Scholar
  3. 3.
    P. Gayrard, J. Orehek, Ch. Grimaud, J. Charpin, Bronchoconstriction due to the inhalation of tobacco smoke: comparison of effects in the normal and asthmatic subject, Bull. Physio. Path. Respir. 1974, 10: 457–461.Google Scholar
  4. 4.
    J.A. Nadel, J.H. Comroe, Acute effects of inhalation of cigarette smoke on airway conductance, J. Appl. Physiol. 1961, 16: 713–716.Google Scholar
  5. 5.
    G.M. Sterling, Mechanism of bronchoconstriction caused by cigarette smoking, Br. Med. J. 1967, 3: 275–277.CrossRefGoogle Scholar
  6. 6.
    S.T. Chiang, B.C. Wang, Acute effects of cigarette smoking on pulmonary function, Am. Rev. Respir. Dis. 1970, 101: 860–868.Google Scholar
  7. 7.
    P. Hamosh, A.M.T. da Silva, The effect on expiratory flow rates of smoking three cigarettes in rapid succession, Chest 1977, 72: 610–613.CrossRefGoogle Scholar
  8. 8.
    B.G. Clarke, A.R. Guyatt, J.H. Alpers, C.M. Fletcher, I.D. Hill, Changes in airway conductance on smoking a cigarette, Thorax 1970, 25: 418–422.CrossRefGoogle Scholar
  9. 9.
    A.R. Guyatt, G. Berry, J.H. Alpera, A.C. Bramley, and C.M. Fletcher, Relationship of airway conductance and its immediate change on smoking to smoking habits and symptoms of chronic bronchitis. Am. Rev. Respir. Dis. 1970, 101: 44–54.Google Scholar
  10. 10.
    T. Higenbottam, D. Hamilton, C. Feyeraband, and T.J.H. Clark, Acute effects of smoking a single cigarette on the airway resistance and the maximal and partial expiratory flow volume curves. Br. J. Dis. Chest 1980, 74: 37–46.CrossRefGoogle Scholar
  11. 11.
    H. Sellick, J.G. Widdicombe, Stimulation of lung irritant receptors by cigarette smoke, carbon dust, and histamine aerosol. J. Appl. Physiol. 1971, 31: 15–19.Google Scholar
  12. 12.
    J.A. Nadel, and D.F. Tierney, Effect of a previous deep inspiration on airway resistance in man, J. Appl. Physiol. 1961, 16: 717–719.Google Scholar
  13. 13.
    P.W. Lord, A.G.F. Brooks, and J.H. Edwards, Variations between observers in the estimation of airways resistance and thoracic gas volume. Thorax 1977, 32: 68–71.Google Scholar
  14. 14.
    A.B. Dubois, S.Y. Botelho, G.N. Bedell, R. Marshall, and J.H. Comroe, A rapid plethysmographic method for measuring thoracic gas volume, J. Clin. Invest. 1956, 35: 322–326.CrossRefGoogle Scholar
  15. 15.
    A.B. Dubois, S.Y. Botelho, J.A. Comroe, A new method for measuring airway resistance in man, using a body plethysmograph. Values in normal subjects and in patients with respiratory disease, J. Clin. Invest. 1956, 35: 327–335.CrossRefGoogle Scholar
  16. 16.
    P.J. Chowienczyk, P.J. Rees, J. Payne, and T.J. H. Clark, A new method for the computer assisted determination of airways resistance, J. Appl. Physiol. 1981, 50: 672–678.Google Scholar
  17. 17.
    Selective filtration of tobacco smoke compounds: a review, Recent Advances in the Chemical Composition of Tobacco and Tobacco Smoke, New Orleans 1977, 553–583.Google Scholar
  18. 18.
    A.M.T. DaSilva, and P. Hamosh, The immediate effect on lung function of smoking filtered and non-filtered cigarettes. Am. Rev. Respir. Dis. 1980, 122: 794–797.Google Scholar
  19. 19.
    A.B. Dubois, L. Dautrebande, Acute effects of breathing inert dust particles and of carbachol aerosol on mechanical characteristics of the lungs in man, Changes in response after inhaling sympathomimetic aerosols, J. Clin. Invest. 1956, 37: 1746–1755.CrossRefGoogle Scholar
  20. 20.
    D.M. Jackson, and I.M. Richards, The effects of sodium cromoglycate on histamine aerosol induced reflex bronchoconstriction in the anaesthetized dog, Br. J. Pharmacol. 1977, 61: 257–262.Google Scholar
  21. 21.
    M.B. Dolovich, R. Sanchis, C. Rossman, and M.T. Newhouse, Aerosol penetrance: a sensitive index of peripheral airways obstruction, J. Appl. Physiol. 1976, 40: 468–471.Google Scholar
  22. 22.
    P.J. Chowienczyk, P.J. Rees, T.J.H. Clark, An automated system for the measurement of airways resistance, lung volumes and flow volume loops, Thorax 1981, in press.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • P. J. Rees
    • 1
  • P. J. Chowienczyk
    • 1
  • T. J. H. Clark
    • 1
  1. 1.Respiratory Function UnitGuy’s HospitalLondonEngland

Personalised recommendations