Skin Tumor Promotion: A Comparative Study of Several Stocks and Strains of Mice

  • John ReinersJr.
  • Kowetha Davidson
  • Kay Nelson
  • Mark Mamrack
  • Thomas Slaga
Part of the Basic Life Sciences book series


Topical application of some chemical carcinogens will induce skin tumors on mice. In general, most chemical carcinogens have to be given repeatedly to induce a large number of tumors (complete carcinogenesis). Skin tumors also can be induced by the sequential application of a single subthreshold dose of a carcinogen (initiation phase) followed by repeated treatment with a noncarcinogenic promoter (promotion phase). This second procedure employing initiation and promotion is referred to as two-stage carcinogenesis.


Mouse Skin Skin Tumor Dark Cell Fluocinolone Acetonide Epidermal Basal Cell 


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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • John ReinersJr.
    • 1
  • Kowetha Davidson
    • 1
  • Kay Nelson
    • 1
  • Mark Mamrack
    • 1
  • Thomas Slaga
    • 1
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA

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