Organ and Species Specificity in Nickel Subsulfide Carcinogenesis

  • F. William SundermanJr.
Part of the Basic Life Sciences book series


The carcinogenic effects of metal compounds in man and experimental animals have been comprehensively reviewed in several recent articles and monographs (1-7). Four metals (arsenic, cadmium, chromium, and nickel) have been established as human carcinogens on the basis of epidemiological investigations, and compounds of 13 metals (aluminum, beryllium, cadmium, cobalt, chromium, copper, iron, manganese, nickel, lead, platinum, titanium, and zinc) have been shown to induce cancers in experimental animals (5-7). Nickel subsulfide (Ni3S2) is the most potent metallic carcinogen that has been identified to date;Ni3S2 has been evaluated for carcinogenicity much more thoroughly and extensively than any other metal compound (3,8-10). Consequently, Ni3S2 has been selected as the focal point for this exposition of organ and species specificity in metal carcinogenesis.


Syrian Hamster Nickel Sulfide Intraocular Injection Heme Oxygenase Activity Buccal Pouch 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • F. William SundermanJr.
    • 1
  1. 1.Departments of Laboratory Medicine and PharmacologyUniversity of Connecticut School of MedicineFarmingtonUSA

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