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Organ Specificity and Interspecies Differences in Carcinogenesis by Metabolism-Independent Alkylating Agents

  • Jerry M. Rice
  • Alan Perantoni
Part of the Basic Life Sciences book series

Abstract

The metabolism-independent or “direct-acting” alkylating agents comprise a structurally diverse group of chemically reactive organic compounds that include some of the most potent known mutagens and carcinogens. Their conversion to reactive intermediates requires no enzyme-mediated catalysis, and in this respect these compounds differ from the great majority of organic chemical carcinogens. Many of the direct-acting alkylating agents have been used in chemical syntheses for decades, and their chemistry is accordingly well known. The carcinogenicity of a number of these compounds has been studied extensively in both rodent and non-rodent species, and the results of such studies provide a remarkable illustration of qualitative interspecies differences in susceptibility to carcinogenesis that cannot be ascribed to differences in metabolism of xenobiotic compounds.

Keywords

Peripheral Nervous System Alkylating Agent Syrian Hamster Interspecies Difference Patas Monkey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Jerry M. Rice
    • 1
  • Alan Perantoni
    • 1
  1. 1.Laboratory of Comparative CarcinogenesisNational Cancer InstituteFrederickUSA

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