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Carcinogenic Risk Assessment—The Consequences of Believing Models

  • Edmund A. C. Crouch
Part of the Basic Life Sciences book series

Abstract

To estimate risks to humans from carcinogens requires extrapolation from animal or other data. Any such extrapolation must be made in the context of a model or models, but no current consensus exists as to which models are correct. There is no shortage of suggested models for this task, each motivated by theoretical arguments, but the differences among them can lead to enormously different predictions. Furthermore, they often lack any practical demonstration of validity.

Keywords

Dose Measure Random Error Term Unit Slope B6C3F1 Mouse Carcinogenic Potency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Guess, H., K. Crump, and R. Peto. 1977. Uncertainty estimates for low-dose-rate extrapolations of animal carcinogenicity data. Cancer Res. 37: 3475–3483.PubMedGoogle Scholar
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    Crouch, E., and R. Wilson. 1979. Interspecies comparison of carcinogenic potency. J. Toxicol. Environ. Hlth. 5: 1095–1118.CrossRefGoogle Scholar
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    Armitage, P., and R. Doll. 1954. The age distribution and a multi-stage theory of carcinogenesis. Brit. J. Cancer V III: 1–12.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Edmund A. C. Crouch
    • 1
  1. 1.Energy and Environmental Policy Center, Jefferson Physics LaboratoryHarvard UniversityCambridgeUSA

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