Trans-Species and Trans-Tissue Extrapolation of Carcinogenicity Assays
From earliest times, mankind has endowed animals with specific human attributes. Language reflects many of these attributes in phrases such as “wise as an owl,” “cunning as a fox,” or “assinine.” Soothsayers have used the detailed morphological examination of outbred animals to predict man’s fate in the future. It is relevant to our present society that none of these attributions were scientific absolutes; they could be manipulated to suit the current political exigencies. Our current mysticism dictates that we regard all agents that induce cancer in animals as having the same effect in man. Although some evidence for this theory exists, and it represents a cautious view, it is again by no means a scientific absolute.
KeywordsCarcinogenic Potency Liver Neoplasia Outbred Animal Detailed Morphological Examination Hepatic Tumorigenesis
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