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Metabolism of Chemical Carcinogens by Tracheobronchial Tissues

  • Herman Autrup
  • Roland C. Grafstrom
  • Curtis C. Harris
Part of the Basic Life Sciences book series

Abstract

Chemical carcinogens are a large group of naturally occurring and man-made compounds of diverse molecular structures. These compounds are ubiquitous in the human environment in the food chain, the water supply, and the atmosphere and they enter the human body through the surface epithelium. The surface area of the lower respiratory tract, approximately 25 m2, is directly exposed to some of these compounds during inhalation. In addition, chemical carcinogens and their metabolites can also reach the lung via the systemic route.

Keywords

High Pressure Liquid Chromatography Epoxide Hydrolase Chemical Carcinogen Polynuclear Aromatic Hydrocarbon Aryl Hydrocarbon Hydroxylase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Herman Autrup
    • 1
  • Roland C. Grafstrom
    • 1
  • Curtis C. Harris
    • 1
  1. 1.Human Tissue Studies Section, Laboratory of Experimental PathologyNational Cancer InstituteBethesdaUSA

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