Abstract
Extensive studies on several species of laboratory animals have been done for only a few carcinogenic aromatic amines or amides; those so tested include benzidine, 4-aminobiphenyl, 2-acetylaminofluorene (AAF), and 2-aminonaphthalene (1). Even for these known carcinogens there are sizable variations in species response; the most striking occurs with AAF where at least 15 species have been tested (2). With this compound the guinea pig, cotton rat, monkey, steppe-lemming, and X/Gf mouse, among the mammals, have shown resistance to the carcinogenic effects. Metabolic studies, either in vivo or in vitro, have not always provided satisfactory explanations for these differences (3,4,5).
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References
Clayson, D.B., and R.C. Garner. 1976. Carcinogenic aromatic amines and related compounds. In: Chemical Carcinogens. C.E. Searle, ed. American Chemical Society: Washington, DC. pp. 366–461.
Weisburger, E.K. 1981. N-Substituted aryl compounds in carcinogenesis and mutagenesis. NCI Monograph 58: 1–7.
Weisburger, E.K. 1981. Metabolic studies in vivo with arylamines. NCI Monograph 58: 95–99.
Razzouk, C., M. Mercier, and M. Roberfroid. 1980. Biochemical basis for the resistance of guinea-pig and monkey to the carcinogenic effects of arylamines and arylamides. Xenobiotica 10: 565–571.
Razzouk, C., M. Mercier, and M. Roberfroid. 1980. Induction, activation, and inhibition of hamster and rat liver microsomal arylamide and arylamine N-hydroxylase. Cancer Res. 40: 3540–3546.
So, B.H., and E.L. Wynder. 1972. Induction of hamster tumors of the urinary bladder by 3,2’-dimethyl-4-aminobiphenyl. J. Nat. Cancer Inst. 48: 1733–1738.
Ward, J.M., G. Reznik, and F.M. Garner. 1980. Proliferative lesions of the spleen in male F344 rats fed diets containing p-chloroaniline. Vet. Pathol. 17: 200–205.
Van Duuren, B.L. 1980. Carcinogenicity of hair dye components. In: Cancer and the Environment. H.B. Demopoulos and M.A. Mehlman, eds. Pathotox Publishers, Inc.: IL. pp. 237–251.
Hayden, D.W., G.G. Wade, and A.H. Handler. 1978. Goitrogenic effect of 4,4’-oxydianiline in rats and mice. Vet. Pathol. 15: 649–662.
Evarts, R.P., and C.A. Brown. 1980. 2,4-Diaminoanisole sulfate: Early effect on thyroid gland morphology and late effect on glandular tissues of Fischer 344 rats. J. Nat. Cancer Inst. 65: 197–204.
Ward, J., S.F. Stinson, J.F. Hardisty, B.Y. Cockrell, and D.W. Hayden. 1979. Neoplasms and pigmentation of the thyroid gland in F344 rats exposed to 2,4-diaminoanisole sulfate, a hair dye component. J. Nat. Cancer Inst. 62: 1067–1073.
Pliss, G.B., M.A. Zabezhinsky. 1970. Carcinogenic properties of orthotolidine (3,3’-dimethylbenzidine). J. Nat. Cancer Inst. 45: 283–295.
Weisburger, E.K., and J.H. Weisburger. 1958. Chemistry, carcinogenicity, and metabolism of 2-fluorenamine and related compounds. Adv. Cancer Res. 5: 331–431.
Krishna Murthy, A.S., J.R. Baker, E.R. Smith, and G.G. Wade. 1977. Development of hemangiosarcomas in B6C3F1 mice fed 2-methyl-l-nitroanthraquinone. Intern. J. Cancer 19: 117–121.
Ward, J.M., R.A. Griesemer, and E.K. Weisburger. 1979. The mouse liver tumor as an endpoint in carcinogenesis tests. Toxic. Appl. Pharmacol. 51: 389–397.
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© 1983 Plenum Press, New York
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Weisburger, E.K. (1983). Species Differences in Response to Aromatic Amines. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_2
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DOI: https://doi.org/10.1007/978-1-4684-4400-1_2
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