Species Differences in Response to Aromatic Amines

  • Elizabeth K. Weisburger
Part of the Basic Life Sciences book series


Extensive studies on several species of laboratory animals have been done for only a few carcinogenic aromatic amines or amides; those so tested include benzidine, 4-aminobiphenyl, 2-acetylaminofluorene (AAF), and 2-aminonaphthalene (1). Even for these known carcinogens there are sizable variations in species response; the most striking occurs with AAF where at least 15 species have been tested (2). With this compound the guinea pig, cotton rat, monkey, steppe-lemming, and X/Gf mouse, among the mammals, have shown resistance to the carcinogenic effects. Metabolic studies, either in vivo or in vitro, have not always provided satisfactory explanations for these differences (3,4,5).


Liver Tumor Aromatic Amine Anthranilic Acid Aniline Hydrochloride Carcinogenic Aromatic Amine 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Elizabeth K. Weisburger
    • 1
  1. 1.Laboratory of Carcinogen MetabolismNational Cancer InstituteBethesdaUSA

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