Endocrine Regulation of Xenobiotic Conjugation Enzymes

  • Coral A. Lamartiniere
  • George W. Lucier
Part of the Basic Life Sciences book series


The balance of events involved in the activation/deactivation of xenobiotics is enormously complex. The metabolic activation of non-toxic chemicals to compounds that are reactive intermediates has been implicated in a wide variety of toxic reactions including carcinogenesis, teratogenesis, and toxicity (1–3). Figure 1 illustrates the enzymatic transformation of benzo[a]pyrene (BP) to reactive intermediates, primarily BP-epoxides. These electrophilic compounds can bind to DNA or to other cellular macromolecules to initiate toxicity. Toxic metabolites of polycyclic aromatic hydrocarbons can be enzymatically deactivated by a number of enzyme systems, such as the glutathione S-transferases, glucuronyltransferases, and sulfotransferases.


Endocrine Regulation Testosterone Propionate Hepatic Glutathione Testosterone Propionate Neonatal Androgen 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Coral A. Lamartiniere
    • 1
  • George W. Lucier
    • 1
  1. 1.Laboratory of Organ Function and ToxicologyNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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