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Endocrine Regulation of Xenobiotic Conjugation Enzymes

  • Coral A. Lamartiniere
  • George W. Lucier
Part of the Basic Life Sciences book series

Abstract

The balance of events involved in the activation/deactivation of xenobiotics is enormously complex. The metabolic activation of non-toxic chemicals to compounds that are reactive intermediates has been implicated in a wide variety of toxic reactions including carcinogenesis, teratogenesis, and toxicity (1–3). Figure 1 illustrates the enzymatic transformation of benzo[a]pyrene (BP) to reactive intermediates, primarily BP-epoxides. These electrophilic compounds can bind to DNA or to other cellular macromolecules to initiate toxicity. Toxic metabolites of polycyclic aromatic hydrocarbons can be enzymatically deactivated by a number of enzyme systems, such as the glutathione S-transferases, glucuronyltransferases, and sulfotransferases.

Keywords

Endocrine Regulation Testosterone Propionate Hepatic Glutathione Testosterone Propionate Neonatal Androgen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Coral A. Lamartiniere
    • 1
  • George W. Lucier
    • 1
  1. 1.Laboratory of Organ Function and ToxicologyNational Institute of Environmental Health SciencesResearch Triangle ParkUSA

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