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Promotion of Urinary Bladder Carcinogenesis

  • Chapter
Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

The relationship of chemicals to urinary bladder carcinogenesis was initially observed in the species of ultimate concern in cancer research -- the human being. Rehn in 1895 noticed an increased incidence of cancer of the urinary bladder in workers in the German aniline dye industry (1,2). Hueper and his colleagues were able to demonstrate that one of the carcinogens to which these workers were exposed was 2-aminonaphthalene. Hueper’s experiments involving dogs also demonstrated the necessity for relatively high doses of the carcinogen and the long periods of time required for the experimental induction of bladder cancer (1,2). Aromatic amines since then have remained of central importance in bladder cancer research in animals and in humans.

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Author information

Authors and Affiliations

  1. Department of Pathology, St. Vincent Hospital, Worcester, Massachusetts, 01604, USA

    Samuel M. Cohen

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  1. Samuel M. Cohen
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Cohen, S.M. (1983). Promotion of Urinary Bladder Carcinogenesis. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_13

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4402-5

  • Online ISBN: 978-1-4684-4400-1

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