Promotion of Urinary Bladder Carcinogenesis

  • Samuel M. Cohen
Part of the Basic Life Sciences book series


The relationship of chemicals to urinary bladder carcinogenesis was initially observed in the species of ultimate concern in cancer research -- the human being. Rehn in 1895 noticed an increased incidence of cancer of the urinary bladder in workers in the German aniline dye industry (1,2). Hueper and his colleagues were able to demonstrate that one of the carcinogens to which these workers were exposed was 2-aminonaphthalene. Hueper’s experiments involving dogs also demonstrated the necessity for relatively high doses of the carcinogen and the long periods of time required for the experimental induction of bladder cancer (1,2). Aromatic amines since then have remained of central importance in bladder cancer research in animals and in humans.


Bladder Cancer Urinary Bladder Aromatic Amine Bladder Tumor Urinary Bladder Cancer 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Samuel M. Cohen
    • 1
  1. 1.Department of PathologySt. Vincent HospitalWorcesterUSA

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