Tissue and Species Specificity for Phorbol Ester Receptors

  • Peter M. Blumberg
  • K. Barry Delclos
  • Susan Jaken
Part of the Basic Life Sciences book series


Tumor promoters are agents that, although not themselves carcinogenic, induce tumors in animals previously treated with a subthreshold dose of a carcinogen (1–3). Although tumor promotion has been characterized in greatest detail for mouse skin, it has also been demonstrated for the liver, bladder, colon, trachea, and mammary gland (4,5). The potential importance of tumor promotion in human cancer etiology is suggested by a growing body of epidemiological evidence (6–8).


Phorbol Ester Mouse Skin Chicken Embryo Fibroblast Particulate Preparation Epidermal Growth Factor Binding 
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Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Peter M. Blumberg
    • 1
  • K. Barry Delclos
    • 1
  • Susan Jaken
    • 1
  1. 1.Department of PharmacologyHarvard Medical SchoolBostonUSA

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