Overview and Perspectives: Natural Resistance Mechanisms
I’ve been asked to summarize today’s session and to give an overview of the field of natural resistance. It would be worthwhile first to go back to the issue raised by Dr. Cudkowicz at the beginning of the session: that there is a heterogeneity of natural effector cells. To think broadly about the natural resistance system, one needs to consider effector cells other than NK cells. This is an important point to reiterate, particularly since we heard in this symposium very little about cells other than NK cells. In order to correct that imbalance, I’ll make some remarks not only about NK cells but also about the so-called natural cytotoxic (NC) cells and about naturally cytotoxic macrophages. For completeness, it should be noted that granulocytes from normal individuals can have at least cytostatic effects against tumor cells as well as their known effects on various microorganisms.
KeywordsStaphylococcal Enterotoxin Large Granular Lymphocyte Natural Cytotoxic Natural Cytotoxic Cell Natural Resistance Mechanism
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- 1.Stutman, O., Paige, C. J., and Figurella, E. F., Natural cytotoxic cells against solid tumors in mice. I. Strain and age distribution of target cell susceptibility, J. Immunology 121:1819, 1978.Google Scholar
- 3.Abo, T., and Balch, C. M., A differentiation antigen on human NK and K cells identified by a monoclonal antibody (HNK-1), J. Immunology 127:1024, 1981.Google Scholar