Role of Natural Killer Cells and of Interferon in Natural Resistance against Virus Infections

  • H. Kirchner
  • H. Engler
  • R. Zawatzky
  • L. Schindler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


There are a number of experimental findings that are fairly well established:
  1. (a)

    Interferons cause an antiviral effect in tissue culture (1).

  2. (b)

    Injection of interferon causes antiviral protection in vivo (for a review see Ref. 2).

  3. (c)

    Injection of a variety of viruses causes rapid interferon production in vivo, both at the infection site (for example in the peritoneal cavity) and in the serum (3).

  4. (d)

    Injection of interferon or interferon inducers (including viruses) causes activation of Natural Killer (NK) cells in vivo (4).



Herpes Simplex Virus Infection Natural Killer Activity Normal Rabbit Serum Peritoneal Exudate Peritoneal Exudate Cell 
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  1. 1.
    Isaacs, A., and Lindenmann, J., Proc. Royal Soc. B 147:258, 1957.CrossRefGoogle Scholar
  2. 2.
    Stewart, W. E., “The Interferon System”, Springer Verlag Wien, New York, 1979.Google Scholar
  3. 3.
    Baron, S., and Buckler, C. E., Science 141:1061, 1963.PubMedCrossRefGoogle Scholar
  4. 4.
    Gidlund, M., Örn, A., Wigzell, H., Senik, A., and Gresser, I., Nature 273:759, 1978.PubMedCrossRefGoogle Scholar
  5. 5.
    Welsh, R. M., Antiviral Res. 1:5, 1981.CrossRefGoogle Scholar
  6. 6.
    Welsh, R. M., and Hallenbeck, L. A., J. Immunol. 124:2491, 1980.PubMedGoogle Scholar
  7. 7.
    Tardieu, M., Héry, C., and Dupuy, J. M., J. Immunol. 124:418, 1980.PubMedGoogle Scholar
  8. 8.
    Bancroft, G. J., Shellam, G. R., and Chalmer, J. E., J. Immunol. 126:988, 1981.PubMedGoogle Scholar
  9. 9.
    Hirsch, R. L., Immunology 43:81, 1981.PubMedGoogle Scholar
  10. 10.
    Welsh, R. M., and Kiessling, R. W., Scand. J. Immunol. 11:363, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Gresser, I., Tovey, M. G., Maury, C., and Bandu, M. T., J. Exp. Med. 144:1316, 1976.PubMedCrossRefGoogle Scholar
  12. 12.
    Engler, H., Zawatzky, R., Goldbach, A., Schröder, C. H., Weyand, C., Hämmerling, G. J., and Kirchner, H., J. Gen. Virol. 55:25, 1981.PubMedCrossRefGoogle Scholar
  13. 13.
    Armerding, D., and Rossiter, H., Immunobiol. 158:369, 1981.CrossRefGoogle Scholar
  14. 14.
    Schröder, C. H., Engler, H., and Kirchner, H., J. Gen. Virol. 52:159, 1981.CrossRefGoogle Scholar
  15. 15.
    Zawatzky, R., Engler, H., and Kirchner, H., J. Gen. Virol., in press, 1982.Google Scholar
  16. 16.
    Kirchner, H., Keyssner, K., Zawatsky, R., and Hilfenhaus, J., Immunobiol. 157:401, 1980.CrossRefGoogle Scholar
  17. 17.
    Lopez, C., Nature 258:152, 1975.PubMedCrossRefGoogle Scholar
  18. 18.
    Kirchner, H., Kochen, M., Hirt, H. M., and Munk, K., Z. Immunforsch. 154:147, 1978.Google Scholar
  19. 19.
    Zawatzky, R., Hilfenhaus, J., and Kirchner, H., Cell. Immunol. 47:424, 1979.PubMedCrossRefGoogle Scholar
  20. 20.
    Lopez, C., Ryshke, R., and Bennett, M., Infect. Immun. 28:1028, 1980.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • H. Kirchner
    • 1
  • H. Engler
    • 1
  • R. Zawatzky
    • 1
  • L. Schindler
    • 1
  1. 1.Institute of Virus ResearchGerman Cancer Research CenterHeidelbergGermany

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