The Role of NK Cells in Resistance of In Vivo Tumors
The significance of natural killing of tumor cells by lymphocytes, previously investigated as an in vitro phenomena, has now been broadened by examining mechanisms of in vivo tumor resistance. Although the origin and differentiation pathway of murine natural killer (NK) cells is not clearly defined, NK cells express the glycolipid marker asialo GMl which is not expressed on mature T or B cells (1,2). Taking advantage of the fact that microliter amounts of intravenously injected anti-GMl antibody could abolish NK activity in vivo, we studied the role of NK cells in the incidence and growth of various tumors.
KeywordsNatural Killer Natural Killer Cell Nude Mouse Bone Marrow Cell Natural Killer Activity
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