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The Effect of C. Parvum Therapy on Intratumoral Macrophage Subpopulations

  • W. H. McBride
  • K. Moore
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Systemic administration of Corynebacterium parvum can cause partial or in a few instances complete (1,2) regression of subcutaneously growing transplanted tumors (3). It is reasonable to suggest that tumor regression of this kind is macrophage mediated in light of the knowledge that C. parvum injected by the same route stimulated the mononuclear phagocyte system into intense prolonged activity (3). In order to test this hypothesis, it seems best to examine the most relevant macrophage population which is within the tumor itself. Previous reports (4,5,6) had suggested that the intratumoral macrophages did not alter in number during C. parvum therapy. We therefore examined activation of Fc receptor expression. In addition to being a useful discriminating index, Fc receptors appear to equate with other indices of macrophage stimulation/activation (7,8,9).

Keywords

Mononuclear Phagocyte System Tumoral Macrophage Macrophage Subpopulation Receptor Bear Cell Repeatable Fashion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Milas, L., Hunter, N., Basic, I., and Withers, H. R., Cancer Res. 34:2470, 1974.PubMedGoogle Scholar
  2. 2.
    Peters, L. J., McBride, W. H., Mason, K. A., and Milas, L., J. Reticuloendothelial Soc. 24:9, 1978.Google Scholar
  3. 3.
    Milas, L., and Scott, M. T., Adv. Cancer Res. 27:257, 1977.Google Scholar
  4. 4.
    Gebhardt, M. C., and Fisher, B., J. Natl. Cancer Inst. 62:1034, 1979.Google Scholar
  5. 5.
    Moore, K., and McBride, W. H., submitted for publication.Google Scholar
  6. 6.
    Thomson, A. W., Cruickshank, N., and Fowler, E. F., Br. J. Cancer 39:578, 1979.CrossRefGoogle Scholar
  7. 7.
    Rhodes, J., Bishop, M., and Benfield, J., Science 203:179, 1979.PubMedCrossRefGoogle Scholar
  8. 8.
    Rhodes, J., J. Immunol. 114:976, 1975.PubMedGoogle Scholar
  9. 9.
    Moore, K., and McBride, W. H., Int. J. Cancer 26:609, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. H. McBride
    • 1
  • K. Moore
    • 1
  1. 1.Department of BacteriologyUniversity of Edinburgh Medical SchoolEdinburghScotland

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