Human Monocyte Killing of Tumor Cells: Contribution of an Extracellular Cytotoxin

  • N. Matthews
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Cells of the macrophage series can be cytostatic or cytotoxic in vitro to certain tumor cell lines but they are usually without effect on non-tirans formed cells. For anti-tumor effects, macrophagetumor cell contact is obligatory in certain systems but not in others where soluble mediators appear to be involved. Such mediators include arginase (1), the C3a complement component (2), cytolytic factor, a serine protease (3), hydrogen peroxide (4) and tumor necrosis factor (5,6,7). The contribution of each of these macromolecular mediators to the total anti-tumor effect of the macrophage is unclear, but could be resolved if neutralizing antisera to the mediators were available.


L929 Cell Human Monocyte Pokeweed Mitogen Antiserum Dilution Cytotoxin Assay 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • N. Matthews
    • 1
  1. 1.Department of Medical MicrobiologyWelsh National School of MedicineHeath Park CardiffUK

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