Human Monocyte Killing of Tumor Cells: Contribution of an Extracellular Cytotoxin
Cells of the macrophage series can be cytostatic or cytotoxic in vitro to certain tumor cell lines but they are usually without effect on non-tirans formed cells. For anti-tumor effects, macrophagetumor cell contact is obligatory in certain systems but not in others where soluble mediators appear to be involved. Such mediators include arginase (1), the C3a complement component (2), cytolytic factor, a serine protease (3), hydrogen peroxide (4) and tumor necrosis factor (5,6,7). The contribution of each of these macromolecular mediators to the total anti-tumor effect of the macrophage is unclear, but could be resolved if neutralizing antisera to the mediators were available.
KeywordsL929 Cell Human Monocyte Pokeweed Mitogen Antiserum Dilution Cytotoxin Assay
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