Activation of Murine Mononuclear Phagocytes for Destroying Tumor Cells: Analysis of Effector Mechanisms and Development

  • D. O. Adams
  • W. J. Johnson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Over the past decade, the original concept of macrophage activation as development of the ability to destroy facultative or obligate intracellular parasites has been broadened to include the destruction of tumor cells (1). Macrophages from sites of infection with such intracellular parasites, when cocultivated with tumor cells, efficiently destroy the tumor cells over several days (1). This form of cytolysis, which has been termed macrophage-mediated tumor cytotoxicity, has generally been found to be selective for tumor cells, to depend upon cell-to-cell contact, and to be independent of either exogenous recognition factors or soluble lytic substances (2,3). In the past two years, it has become apparent that macrophages can also be activated for destroying tumor cells in another, quite distinct circumstance — the lysis of antibody-coated tumor targets (antibody-dependent cellular cytotoxicity or ADCC) (4,5). Considerable evidence has been amassed that activation of macrophages is an important host defense against the development and spread of neoplasms in vivo (1–3).

Keywords

Lymphoma Leukemia Sarcoma Arginine Prostaglandin 

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References

  1. 1.
    Hibbs, J. B., Remington, J. S., and Stewart, C. C., Pharmacol. Ther. 8:37, 1980.CrossRefGoogle Scholar
  2. 2.
    Evans, R., and Alexander, P., in “Immunobiology of the Macrophage”, p. 536, (D. S. Nelson, ed.), Academic Press, New York, 1976.Google Scholar
  3. 3.
    Keller, R., in “The Macrophage and Cancer” (K. James, B. McBride and A. Stewart, eds.), pp. 31-49, 1977.Google Scholar
  4. 4.
    Koren, H. S., and Adams, D. O., in “Macrophage Mediated Antibody-Dependent Cellular Cytotoxicity” (H. S. Koren, ed.), Plenum Press, New York, in press.Google Scholar
  5. 5.
    Nathan, C. F., Fed. Proc., in press, April, 1982.Google Scholar
  6. 6.
    Adams, D. O., and Marino, P., in “Contemporary Hematology-Oncology”, vol. III, (A. S. Gordon, R. Silber and J. LoBue, eds.), Plenum Publishing Corp., New York, in preparation, 1982.Google Scholar
  7. 7.
    Meltzer, M. S., Tucker, R. W., and Breuer, A. C., Cell. Immunol. 17:30, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Stewart, C., Adles, C., and Hibbs, J.B., in “The RES in Health and Disease”, (H. Friedman, M. Escobar, and S. Reichard, eds.). Plenum Press, New York, 1975.Google Scholar
  9. 9.
    Piessens, W., Cell. Immunol. 35:303, 1978.PubMedCrossRefGoogle Scholar
  10. 10.
    Marino, P. A., and Adams, D. O., Cell. Immunol. 54:11, 1980.PubMedCrossRefGoogle Scholar
  11. 11.
    Somers, S. D., and Adams, D. O., manuscript in preparation, 1982.Google Scholar
  12. 12.
    Johnson, W. J., Whisnant, C. C., and Adams, D. O., J. Immunol. 127:1787, 1981.PubMedGoogle Scholar
  13. 13.
    Hollenberg, M. D., and Cuatrecasas, P., in “The Receptors”, Vol. 1, General Principles and Procedures, Plenum Publishing Corp., New York, 1979.Google Scholar
  14. 14.
    Adams, D. O., Johnson, W. J., and Marino, P. A., Fed. Proc., in press, April, 1982.Google Scholar
  15. 15.
    Somers, S. D., and Adams, D. O., in “Natural Cell-Mediated Immunity. II” (R. Herberman, ed.), Academic Press, New York, in press, 1982.Google Scholar
  16. 16.
    Marino, P. A., Whisnant, C. C., and Adams, D. O., J. Exp. Med. 154:77, 1981.PubMedCrossRefGoogle Scholar
  17. 17.
    Adams, D. O., Marino, P. A., and Meltzer, M. S., J. Immunol. 126:1843, 1981.PubMedGoogle Scholar
  18. 18.
    Adams, D. O., and Marino, P. A., J. Immunol. 126:981, 1981.PubMedGoogle Scholar
  19. 19.
    Adams, D. O., Kao, K. J., Farb, R., and Pizzo, S. V., J. Immunol. 124:293, 1980.PubMedGoogle Scholar
  20. 20.
    Adams, D. O., J. Immunol. 124:286, 1980.PubMedGoogle Scholar
  21. 21.
    Johnson, W. J., Weiel, J. E., and Adams, D. O., in “Natural Cell-Mediated Immunity. II.” (R. Herberman, ed.), Academic Press, New York, in press, 1982.Google Scholar
  22. 22.
    Adams, D. O., Johnson, W. J., Fiorito, E., and Nathan, C. F., J. Immunol. 127:1973, 1981.PubMedGoogle Scholar
  23. 23.
    Johnson, W. J., and Adams, D. O., unpublished observations, 1982.Google Scholar
  24. 24.
    Hibbs, J. B., Taintor, R. R., Chapman, H. A., and Weinberg, J. B., Science 197:279, 1977.PubMedCrossRefGoogle Scholar
  25. 25.
    Meltzer, M. S., Lymphokines 3:319, 1981.Google Scholar
  26. 26.
    Russell, S. W., Doe, W. F., and Mclntosh, A. T., J. Exp. Med. 146:1151, 1977.CrossRefGoogle Scholar
  27. 27.
    Buchmüller, Y., and Mauel, J., J. Exp. Med. 150:359, 1979.PubMedCrossRefGoogle Scholar
  28. 28.
    Cohn, Z. A., J. Immunol. 121:813, 1978.PubMedGoogle Scholar
  29. 29.
    Adams, D. O., and Dean, J. H., in “Natural Cell-Mediated Immunity. II.” (R. Herberman, ed.), Academic Press, New York, in press, 1982.Google Scholar
  30. 30.
    Adams, D. O., Johnson, W. J., and Marino, P. A., manuscript in preparation, 1982.Google Scholar
  31. 31.
    Nathan, C. F., and Root, R. K., J. Exp. Med. 146:1648, 1977.PubMedCrossRefGoogle Scholar
  32. 32.
    Edelson, P., Lymphokines 3:57, 1981.Google Scholar
  33. 33.
    Ezekowitz, R. A. B., Austyn, J., Stahl, P. D., and Gomer, S., J. Exp. Med. 154:60, 1981.PubMedCrossRefGoogle Scholar
  34. 34.
    Beller, D. I., Kiely, J., and Unkeless, E., J. Immunol. 124:1426, 1980.PubMedGoogle Scholar
  35. 35.
    Imber, M. J., Pizzo, S. V., Johnson, W. J., and Adams, D. O., J. Cell Biol., in press, 1982.Google Scholar
  36. 36.
    Marino, P., and Adams, D. O., J. Immunol., in press, 1982.Google Scholar
  37. 37.
    Johnson, W. J. Pizzo, S. V., Imber, M. J., and Adams, D. O., submitted for publication, 1982.Google Scholar
  38. 38.
    Adams, D. O., Johnson, W. J., Marino, P., and Dean, J., submitted for publication, 1982.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. O. Adams
    • 1
  • W. J. Johnson
    • 1
  1. 1.Departments of Pathology and Microbiology-ImmunologyDuke University Medical CenterDurhamUSA

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