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Glucan Immunomodulation in Experimental E. Coli Sepsis

  • David L. Williams
  • William Browder
  • Rose McNamee
  • Nicholas R. Di Luzio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

In spite of the increased efficacy of antibiotic therapy, sepsis, particularly with endotoxin containing gram-negative bacilli, is a serious complication in patients whose defense mechanisms have been compromised by such events as trauma, burns, hematological malignancies, x-irradiation or therapy (1,2). While a number of defects in homeostatic mechanisms have been identified in such patients, attempts to significantly alter host defense mechanisms in order to modify gram-negative sepsis have been limited, since all currently employed experimental immunotherapeutic agents profoundly increase the sensitivity of the host to endotoxins. These agents include Bacillus Calmette-Guérin (3), zymosan (4), C. parvum (5), glucan (6) and muramyl dipeptide (7).

Keywords

Macrophage Function Methyl Palmitate Muramyl Dipeptide Murine Hepatitis Virus Glucose Control Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    McCabe, W. R., and Jackson, G. G., Arch. Intern. Med. 127:120, 1971.CrossRefGoogle Scholar
  2. 2.
    Kreger, B. E., Craven, D. E., Carling, P. C., and McCabe, W. R., Am. J. Med. 68:332, 1980.PubMedCrossRefGoogle Scholar
  3. 3.
    Suter, E., J. Immunol. 92:49, 1964.PubMedGoogle Scholar
  4. 4.
    Benacerraf, B., Thorbecke, G. J., and Jacoby, D., Proc. Soc. Exp. Biol. Med. 100:796, 1959.PubMedGoogle Scholar
  5. 5.
    Ferluga, J., Kaplun, A., and Allison, A. C., Agents and Actions 9:566, 1979.PubMedCrossRefGoogle Scholar
  6. 6.
    Di Luzio, N. R., and Crafton, C. G., Adv. Exp. Med. Biol. 9:27, 1970.Google Scholar
  7. 7.
    Ribi, E. E., Cantrell, J. L., Von Eschen, K. B., and Schwartzman, S. N., Cancer Research 39:4756, 1979.PubMedGoogle Scholar
  8. 8.
    Di Luzio, N. R., Adv. Exp. Med. Biol., 73A:412, 1976.Google Scholar
  9. 9.
    Wooles, W. R., and Di Luzio, N. R., Am. J. Physiol. 203:404, 1962.PubMedGoogle Scholar
  10. 10.
    Wooles, W. R., and Di Luzio, N. R., Science 142:1078, 1963.PubMedCrossRefGoogle Scholar
  11. 11.
    Di Luzio, N. R., and Williams, D. L., Infec. Immun. 20:804, 1978.Google Scholar
  12. 12.
    Reynolds, J. A., Kastello, M. D., Harrington, D. G., Crabbs, C. L., Peters, C. J., Jemski, J. V., Scott, G. H., and Di Luzio, N. R., Infec. Immun. 30:51, 1980.Google Scholar
  13. 13.
    Song, M., and Di Luzio, N. R., Lysozymes in Biology Pathology 6:533, 1979.Google Scholar
  14. 14.
    Williams, D. L., and Di Luzio, N. R., Science 208:67, 1980.PubMedCrossRefGoogle Scholar
  15. 15.
    Williams, D. L., Cook, J. A., Hoffman, E. O., and Di Luzio, N. R., J. Reticuloendothelial Soc. 23:479, 1978.Google Scholar
  16. 16.
    Cook, J. A., Holbrook T. W., and Parker, B. W., J. Reticuloendothelial Soc. 27:567, 1980.Google Scholar
  17. 17.
    Di Luzio, N. R., Lysosomes in Biology Pathology 6:447, 1979.Google Scholar
  18. 18.
    Jennings, M., Jennings, L., Robson, M., and Heggers, J., Can. J. Microbiol. 26:175, 1980.PubMedCrossRefGoogle Scholar
  19. 19.
    Hau, T., Hoffman, R., and Simmons, R. L., Surgery 83:223, 1978.PubMedGoogle Scholar
  20. 20.
    Hau, T., and Simmons, R. L., Surgery 87:588, 1980.PubMedGoogle Scholar
  21. 21.
    Hau, T., Lee, J. T., and Simmons, R. L., Surgery 89:187, 1981.PubMedGoogle Scholar
  22. 22.
    Grover, G. J., and Loegering, D. J., Proc. Soc. Exp. Biol. Med. 167:30, 1981.PubMedGoogle Scholar
  23. 23.
    Burgaleta, C., and Golde, D. W., in “Immune Modulation and Control of Neoplasia by Adjuvant Therapy” (M. A. Chirigos, ed.), p. 195, Raven Press, New York, 1978.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • David L. Williams
    • 1
  • William Browder
    • 2
  • Rose McNamee
    • 1
  • Nicholas R. Di Luzio
    • 1
  1. 1.Department of PhysiologyTulane University School of MedicineNew OrleansUSA
  2. 2.Department of SurgeryTulane University School of MedicineNew OrleansUSA

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