Glucan Immunomodulation in Experimental E. Coli Sepsis

  • David L. Williams
  • William Browder
  • Rose McNamee
  • Nicholas R. Di Luzio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


In spite of the increased efficacy of antibiotic therapy, sepsis, particularly with endotoxin containing gram-negative bacilli, is a serious complication in patients whose defense mechanisms have been compromised by such events as trauma, burns, hematological malignancies, x-irradiation or therapy (1,2). While a number of defects in homeostatic mechanisms have been identified in such patients, attempts to significantly alter host defense mechanisms in order to modify gram-negative sepsis have been limited, since all currently employed experimental immunotherapeutic agents profoundly increase the sensitivity of the host to endotoxins. These agents include Bacillus Calmette-Guérin (3), zymosan (4), C. parvum (5), glucan (6) and muramyl dipeptide (7).


Macrophage Function Methyl Palmitate Muramyl Dipeptide Murine Hepatitis Virus Glucose Control Group 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • David L. Williams
    • 1
  • William Browder
    • 2
  • Rose McNamee
    • 1
  • Nicholas R. Di Luzio
    • 1
  1. 1.Department of PhysiologyTulane University School of MedicineNew OrleansUSA
  2. 2.Department of SurgeryTulane University School of MedicineNew OrleansUSA

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