Macrophage Activation and Effector Mechanisms against Microbes

  • Jacques Mauel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


This review is concerned with some of the mechanisms whereby macrophages destroy intracellular microorganisms, as well as with processes allowing pathogens to elude the microbicidal machinery directed at them. Considerable insight has been gained recently in this area, thanks particularly to detailed investigations into the interaction of macrophages with certain intracellular protozoa. Thus, the various points to be discussed will be illustrated by examples taken from the study of the behavior in macrophages of both prokaryotic and eukaryotic parasites, including Toxoplasma, spp., Trypanosoma spp. and Leishmania spp. The latter three species of microorganisms are pathogenic to man; such studies thus represent more than a fascinating academic exercise, as they are expected to provide fresh leads for the formulation of new therapeutic approaches.


Respiratory Burst Chronic Granulomatous Disease Mononuclear Phagocyte Intracellular Survival Mycobacterium Leprae 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jacques Mauel
    • 1
  1. 1.Institute of BiochemistryWHO Immunology Research and Training CentreEpalingesSwitzerland

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