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Macrophage Activation and Effector Mechanisms against Microbes

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Macrophages and Natural Killer Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 155))

Abstract

This review is concerned with some of the mechanisms whereby macrophages destroy intracellular microorganisms, as well as with processes allowing pathogens to elude the microbicidal machinery directed at them. Considerable insight has been gained recently in this area, thanks particularly to detailed investigations into the interaction of macrophages with certain intracellular protozoa. Thus, the various points to be discussed will be illustrated by examples taken from the study of the behavior in macrophages of both prokaryotic and eukaryotic parasites, including Toxoplasma, spp., Trypanosoma spp. and Leishmania spp. The latter three species of microorganisms are pathogenic to man; such studies thus represent more than a fascinating academic exercise, as they are expected to provide fresh leads for the formulation of new therapeutic approaches.

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Author information

Authors and Affiliations

  1. Institute of Biochemistry, WHO Immunology Research and Training Centre, 1066, Epalinges, Switzerland

    Jacques Mauel

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  1. Jacques Mauel
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Editor information

Editors and Affiliations

  1. College of Medicine, University of Florida, Gainesville, Florida, USA

    Sigurd J. Normann

  2. Department of Medicine, Swiss Research Institute, Davos, Switzerland

    Ernst Sorkin

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© 1982 Plenum Press, New York

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Mauel, J. (1982). Macrophage Activation and Effector Mechanisms against Microbes. In: Normann, S.J., Sorkin, E. (eds) Macrophages and Natural Killer Cells. Advances in Experimental Medicine and Biology, vol 155. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4394-3_74

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  • DOI: https://doi.org/10.1007/978-1-4684-4394-3_74

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4396-7

  • Online ISBN: 978-1-4684-4394-3

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