α2M-Proteinase Complexes are Taken up by Macrophages During Joint Inflammation

  • T. L. Vischer
  • E. Flory
  • K. Muirden
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


During inflammation, proteinases are released by inflammatory and tissue cells. The activation of the complement, the coagulation and the fibrinolytic systems produces additional proteinases. Active proteinases become inactivated by various inhibitors in the circulation and tissues. Among the plasma proteinase inhibitors, alpha1 -antiproteinase and α2-macroglobulin (α2M) are most abundant (1). The α2M-proteinase complexes are removed from the circulation by fixed tissue macrophages in the liver and spleen and broken down (2,3). In the experiments summarized in this paper, we have looked for the presence of α2M-proteinase complexes in phagocytic cells of synovial tissues and exudates from patients with joint diseases. In parallel, we established that only α2M-proteinase complexes and not free α2M or proteinases are taken up by phagocytic cells.


Synovial Tissue Phagocytic Cell Joint Inflammation Cytoplasmic Inclusion Fibrinolytic System 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • T. L. Vischer
    • 1
    • 2
  • E. Flory
    • 1
    • 2
  • K. Muirden
    • 1
    • 2
  1. 1.Division of RheumatologyHôpital Cantonal UniversitaireGenevaSwitzerland
  2. 2.Department of MedicineUniversity of MelbourneAustralia

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