Fibronectin: A Mediator of Phagocytosis and Its Potential in Treating Septic Shock

  • Frank A. Blumenstock
  • Thomas M. Saba
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Clearance of certain types of particulate matter from the circulation by the cells of the RES is dependent upon the presence of specific proteins in the plasma which support the clearance process by opsonization (1,2,3). One protein actively involved in mediating RES clearance of non-bacterial particulates is a large plasma glycoprotein referred to as α2 surface binding (SB) glycoprotein (4,5). This protein, which has been known by a number of terms, was originally demonstrated by its depletion from the plasma of animals subjected to RES blockade with gelatinized colloid. In these studies, the in vitro support of hepatic macrophage uptake of colloid by plasma from blockaded animals was directly proportional to the deficit in in vivo RE clearance observed following intravascular colloid injection (6). The in vitro activity of this opsonizing protein was demonstrated to be heparin dependent, cryoprecipitable from plasma in the presence of heparin and relatively sensitive to heat denaturation (7,8). Early biochemical characterization of this particular opsonin demonstrated that it was non-immunoglobulin in nature and independent of the complement system (9,10). Further, it was probably identical to a plasma factor which had been described earlier as being functional in the RES clearance of gelatinized radiogold (11).


Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Plasma Factor Plasma Fibronectin Fibrin Monomer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Frank A. Blumenstock
    • 1
  • Thomas M. Saba
    • 1
  1. 1.Department of PhysiologyAlbany Medical College of Union UniversityAlbanyUSA

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