Ia and Macrophages in Alloproliferation and Allocytotoxicity
Current experiments on primary allogeneic responses in our laboratory are based on the observation that the prototype macrophage washed out of the peritoneal cavity does not stimulate allogeneic T cell proliferation in vitro (1) but does stimulate T helper cell induction (2) and cloned antigen specific T helper cells (3). The dendritic cell which clearly differs from a conventional macrophage is exceptional in its efficiency in primary mixed lymphocyte culture (MLC) stimulation (1). Another contrast of major immunologic relevance between these two cell types is that peritoneal macrophages do not express Ia (or Class II MHC products) on their surface to any great extent (usual range 5–10% specific fluorescence) whereas dendritic cells are strongly Ia positive (70–80%).
KeywordsDendritic Cell Spleen Cell Accessory Cell Peritoneal Cell Mixed Lymphocyte Culture
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