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Ia and Macrophages in Alloproliferation and Allocytotoxicity

  • D. R. Katz
  • A. A. Czitrom
  • Marc Feldmann
  • G. H. Sunshine
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)

Abstract

Current experiments on primary allogeneic responses in our laboratory are based on the observation that the prototype macrophage washed out of the peritoneal cavity does not stimulate allogeneic T cell proliferation in vitro (1) but does stimulate T helper cell induction (2) and cloned antigen specific T helper cells (3). The dendritic cell which clearly differs from a conventional macrophage is exceptional in its efficiency in primary mixed lymphocyte culture (MLC) stimulation (1). Another contrast of major immunologic relevance between these two cell types is that peritoneal macrophages do not express Ia (or Class II MHC products) on their surface to any great extent (usual range 5–10% specific fluorescence) whereas dendritic cells are strongly Ia positive (70–80%).

Keywords

Dendritic Cell Spleen Cell Accessory Cell Peritoneal Cell Mixed Lymphocyte Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sunshine, G. H., Katz, D. R., Czitrom, A.A., Eur. J. Immunol. 12:9, 1982.PubMedCrossRefGoogle Scholar
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    Beller, D. I., Kiely, J. M., and Unanue, E., J. Immunol. 124:1426, 1980.PubMedGoogle Scholar
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    Czitron, A. A., Katz, D. R., Sunshine, G. H., Immunology, 1982, in press.Google Scholar
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    Cullen, S. E., Kindle, C. S., Shreffler, D. C., and Corning, C., J. Immunol. 127:1478, 1981.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • D. R. Katz
    • 1
  • A. A. Czitrom
    • 1
  • Marc Feldmann
    • 1
  • G. H. Sunshine
    • 1
  1. 1.I.C.R.F., Tumour Immunology Unit Department of ZoologyUniversity College LondonLondonUK

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