Antigen Presentation In Vitro by a Murine Macrophage Cell Line

  • Yolande Buchmüller
  • Jacques Mauël
  • Giampietro Corradin
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Macrophages have been shown to play a central role in the elicitation of immune responses. One of their multiple functions is the presentation of antigen in a proper form to naive or immune T cells. The biochemical steps involved in this process are not well understood. The availability of a macrophage cell line capable of supporting an antigen-driven T cell proliferation would certainly aid in the elucidation of the biochemical and cellular requirements for antigen presentation. To this purpose, the murine macrophage cell line IC-21 was tested to see whether or not it was capable of presenting soluble and particulate antigens.


Migration Inhibitory Factor Cell Blast Murine Peritoneal Macrophage Murine Macrophage Cell Line Normal Mouse Serum 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Yolande Buchmüller
    • 1
  • Jacques Mauël
    • 1
  • Giampietro Corradin
    • 1
  1. 1.Institute of BiochemistryUniversity of LausanneEpalingesSwitzerland

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