Immunological Surveillance Versus Immunological Stimulation of Oncogenesis- a Formal Proof of the Stimulation Hypothesis
When I was first introduced to cancer research in 1949, the immune mechanism was characterized by the attributes of specificity and memory, and the function of the thymus was unknown. We now have some knowledge of the role of the thymus and the definition of an immune reaction seems to have undergone a radical change. For example, a cell of the lymphoid family that has little specificity and is apparently unassociated with any form of memory, the so-called NK cell, is now promoted as the possible agent of immunological surveillance. Apparently, any function of any leucocyte is now deemed to be immunologic regardless of questions of specificity or memory.
KeywordsShort Latency Primary Host Immunogenic Tumor Secondary Host Immunological Surveillance
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