Prostaglandin E2 is a Feed-Back Regulator of Macrophage Activation
Phagocytosis is a main function of macrophages and a powerful stimulus of macrophage differentiation (1). When quiescent macrophages are induced to phagocytose, a number of immediate responses are observed: (a) respiratory burst with release of Superoxide and H2O2; (b) release of arachidonic acid oxygenation products (3) and (c) secretion of lysosomal hydrolases (1,4). The delayed consequence of phagocytosis is a differentiation or activation process characterized by an increased production of cellular and export proteins that result in cell growth and the expression of novel secretory functions.
KeywordsPlasminogen Activator Macrophage Activation Respiratory Burst Lysosomal Hydrolase Hexose Monophosphate
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- 3.Davies, P., Bonney, R. J., Humes, J. L., and Kuehl, Jr., F. A., in “Mononuclear Phagocytes. Functional Aspects, Part II” (R. van Furth, ed.), pp. 1317–1345, Martinus Nijhoff Publishers, The Hague/Boston/London, 1980.Google Scholar