Prostaglandin E2 is a Feed-Back Regulator of Macrophage Activation

  • Jörg Schnyder
  • Beatrice Dewald
  • Marco Baggiolini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 155)


Phagocytosis is a main function of macrophages and a powerful stimulus of macrophage differentiation (1). When quiescent macrophages are induced to phagocytose, a number of immediate responses are observed: (a) respiratory burst with release of Superoxide and H2O2; (b) release of arachidonic acid oxygenation products (3) and (c) secretion of lysosomal hydrolases (1,4). The delayed consequence of phagocytosis is a differentiation or activation process characterized by an increased production of cellular and export proteins that result in cell growth and the expression of novel secretory functions.


Plasminogen Activator Macrophage Activation Respiratory Burst Lysosomal Hydrolase Hexose Monophosphate 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Schnyder, J., and Baggiolini, M., J. Exp. Med. 148:1449, 1978.PubMedCrossRefGoogle Scholar
  2. 2.
    Badwey, J. A., and Karnovsky, M. L., Ann. Rev. Biochem. 49:695, 1980.PubMedCrossRefGoogle Scholar
  3. 3.
    Davies, P., Bonney, R. J., Humes, J. L., and Kuehl, Jr., F. A., in “Mononuclear Phagocytes. Functional Aspects, Part II” (R. van Furth, ed.), pp. 1317–1345, Martinus Nijhoff Publishers, The Hague/Boston/London, 1980.Google Scholar
  4. 4.
    Davies, P., Page, R. C., and Allison, A. C., J. Exp. Med. 139:1262, 1974.PubMedCrossRefGoogle Scholar
  5. 5.
    Schnyder, J., and Baggiolini, M., J. Exp. Med. 148:435, 1978.PubMedCrossRefGoogle Scholar
  6. 6.
    Edelson, P. J., and Erbs, C., J. Exp. Med. 147:77, 1978.PubMedCrossRefGoogle Scholar
  7. 7.
    Schnyder, J., and Baggiolini, M., Proc. Natl. Acad. Sci. USA 77:414, 1980.PubMedCrossRefGoogle Scholar
  8. 8.
    Brune, K., Glatt, M., Kälin, H., and Peskar, B. A., Nature 274:261, 1978.PubMedCrossRefGoogle Scholar
  9. 9.
    Schnyder, J., Dewald, B., and Baggiolini, M., Prostaglandins 22:411, 1981.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jörg Schnyder
    • 1
  • Beatrice Dewald
    • 1
  • Marco Baggiolini
    • 1
  1. 1.Wander Research Institute, a Sandoz research unit Wander Ltd.BerneSwitzerland

Personalised recommendations